Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mic...
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Autores principales: | , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/83659 |
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I19-R120-10915-83659 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Exactas Ciencias Médicas Chikungunya virus arthritis myositis |
spellingShingle |
Ciencias Exactas Ciencias Médicas Chikungunya virus arthritis myositis Rulli, Néstor E. Rolph, Michael S. Srikiatkhachorn, Anon Anantapreecha, Surapee Guglielmotti, Angelo Mahalingam, Suresh Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
topic_facet |
Ciencias Exactas Ciencias Médicas Chikungunya virus arthritis myositis |
description |
Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infectedmice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans. |
format |
Articulo Articulo |
author |
Rulli, Néstor E. Rolph, Michael S. Srikiatkhachorn, Anon Anantapreecha, Surapee Guglielmotti, Angelo Mahalingam, Suresh |
author_facet |
Rulli, Néstor E. Rolph, Michael S. Srikiatkhachorn, Anon Anantapreecha, Surapee Guglielmotti, Angelo Mahalingam, Suresh |
author_sort |
Rulli, Néstor E. |
title |
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
title_short |
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
title_full |
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
title_fullStr |
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
title_full_unstemmed |
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
title_sort |
protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/83659 |
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Repositorios |
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