Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form

The present study was aimed to evaluate the suitability of a newly synthesized polymer methylcellulose glutarate (MCG) for sustained release matrix system using antihypertensive drug captopril. Methylcellulose glutarate was first prepared using methylcellulose and glutaric anhydride with 1:0.5 ratio...

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Autores principales: Ali, Yasir, Idrees, Muneeb A., Rahman, Nisar-ur-, Mohsin, Sabeeh, Ahmed, Saeed, Ahmed, Irshad
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Captopril
Metilcelulosa
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8361
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8361
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Captopril
Metilcelulosa
spellingShingle Farmacia
Captopril
Metilcelulosa
Ali, Yasir
Idrees, Muneeb A.
Rahman, Nisar-ur-
Mohsin, Sabeeh
Ahmed, Saeed
Ahmed, Irshad
Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
topic_facet Farmacia
Captopril
Metilcelulosa
description The present study was aimed to evaluate the suitability of a newly synthesized polymer methylcellulose glutarate (MCG) for sustained release matrix system using antihypertensive drug captopril. Methylcellulose glutarate was first prepared using methylcellulose and glutaric anhydride with 1:0.5 ratio and confirmed with FTIR, NMR and MALDI. MCG was then employed in various amounts with fixed amount of captopril for the preparation of matrix tablets. Decreasing the amount of MCG had no considerable sustaining effect on in vitro drug release from the matrix system. MCG was also evaluated at different pH values and stirring speed and no appreciable difference in the release profiles was noticed. Moreover, dissolution data of optimum formulation followed zero-order kinetic
format Articulo
Articulo
author Ali, Yasir
Idrees, Muneeb A.
Rahman, Nisar-ur-
Mohsin, Sabeeh
Ahmed, Saeed
Ahmed, Irshad
author_facet Ali, Yasir
Idrees, Muneeb A.
Rahman, Nisar-ur-
Mohsin, Sabeeh
Ahmed, Saeed
Ahmed, Irshad
author_sort Ali, Yasir
title Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
title_short Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
title_full Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
title_fullStr Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
title_full_unstemmed Sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
title_sort sustained release of captopril from matrix tablet using methylcellulose in a new derivative form
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8361
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_5.pdf
work_keys_str_mv AT aliyasir sustainedreleaseofcaptoprilfrommatrixtabletusingmethylcelluloseinanewderivativeform
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AT rahmannisarur sustainedreleaseofcaptoprilfrommatrixtabletusingmethylcelluloseinanewderivativeform
AT mohsinsabeeh sustainedreleaseofcaptoprilfrommatrixtabletusingmethylcelluloseinanewderivativeform
AT ahmedsaeed sustainedreleaseofcaptoprilfrommatrixtabletusingmethylcelluloseinanewderivativeform
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bdutipo_str Repositorios
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