Antidiabetic principle from Eclipta prostrata
The methanol extract of the whole plant of Eclipta prostrata and one of its isolated compounds, eclalbasaponin II were administered to alloxan-induced diabetic rats for 28 and 7 consecutive days, respectively. During the study, a potent antidiabetic activity was observed. Blood sugar was significant...
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Autores principales: | , , , , , |
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Formato: | Articulo Comunicacion |
Lenguaje: | Inglés |
Publicado: |
2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8355 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_7.pdf |
Aporte de: |
id |
I19-R120-10915-8355 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Extractos Vegetales diabetes antidiabetic; Eclipta prostrata; saponin; elalbasaponin Plantas Medicinales |
spellingShingle |
Farmacia Extractos Vegetales diabetes antidiabetic; Eclipta prostrata; saponin; elalbasaponin Plantas Medicinales Rahman, Mohammad S. Rahman, Mohammed Z. Begum, Bilkis Chowdhury, Rasheduzzaman Islam, Sk. Nazrul Rashid, Mohammad A. Antidiabetic principle from Eclipta prostrata |
topic_facet |
Farmacia Extractos Vegetales diabetes antidiabetic; Eclipta prostrata; saponin; elalbasaponin Plantas Medicinales |
description |
The methanol extract of the whole plant of Eclipta prostrata and one of its isolated compounds, eclalbasaponin II were administered to alloxan-induced diabetic rats for 28 and 7 consecutive days, respectively. During the study, a potent antidiabetic activity was observed. Blood sugar was significantly (p < 0.001) reduced by E. prostrata extract (300 mg/kg) and eclalbasaponin II (10 mg/kg), as compared to untreated diabetic rats. Analyses of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) showed no significant (p < 0.001) hepatotoxicity by E. prostrata extractive in alloxan-induced diabetic rats when compared to the diabetic control rats. |
format |
Articulo Comunicacion |
author |
Rahman, Mohammad S. Rahman, Mohammed Z. Begum, Bilkis Chowdhury, Rasheduzzaman Islam, Sk. Nazrul Rashid, Mohammad A. |
author_facet |
Rahman, Mohammad S. Rahman, Mohammed Z. Begum, Bilkis Chowdhury, Rasheduzzaman Islam, Sk. Nazrul Rashid, Mohammad A. |
author_sort |
Rahman, Mohammad S. |
title |
Antidiabetic principle from Eclipta prostrata |
title_short |
Antidiabetic principle from Eclipta prostrata |
title_full |
Antidiabetic principle from Eclipta prostrata |
title_fullStr |
Antidiabetic principle from Eclipta prostrata |
title_full_unstemmed |
Antidiabetic principle from Eclipta prostrata |
title_sort |
antidiabetic principle from eclipta prostrata |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/8355 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_7.pdf |
work_keys_str_mv |
AT rahmanmohammads antidiabeticprinciplefromecliptaprostrata AT rahmanmohammedz antidiabeticprinciplefromecliptaprostrata AT begumbilkis antidiabeticprinciplefromecliptaprostrata AT chowdhuryrasheduzzaman antidiabeticprinciplefromecliptaprostrata AT islamsknazrul antidiabeticprinciplefromecliptaprostrata AT rashidmohammada antidiabeticprinciplefromecliptaprostrata |
bdutipo_str |
Repositorios |
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1764820488760066048 |