Pharmaceutical development of paracetamol oral suspension

The aims of this work are obtaining and evaluating paracetamol oral suspension 32 mg/mL by qualitative and quantitative planning of the ingredients. The observations of the physical-chemical formulations were based in comparison with the specifications of paracetamol solution contained in the Brazil...

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Autores principales: Silva, Felícia P. S., Soares, Janete S., Rolim, Larissa A., Lyra, Magalí A. M. de, Silva, Keyla E.R. da, Silva, Rosali M. F. da, Rolim Neto, Pedró José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
paracetamol; planning excipients; physical-chemical control; suspension
Analgésicos
Vías de Administración de Medicamentos
Farmacopea Brasileña
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8337
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8337
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
paracetamol; planning excipients; physical-chemical control; suspension
Analgésicos
Vías de Administración de Medicamentos
Farmacopea Brasileña
spellingShingle Farmacia
paracetamol; planning excipients; physical-chemical control; suspension
Analgésicos
Vías de Administración de Medicamentos
Farmacopea Brasileña
Silva, Felícia P. S.
Soares, Janete S.
Rolim, Larissa A.
Lyra, Magalí A. M. de
Silva, Keyla E.R. da
Silva, Rosali M. F. da
Rolim Neto, Pedró José
Pharmaceutical development of paracetamol oral suspension
topic_facet Farmacia
paracetamol; planning excipients; physical-chemical control; suspension
Analgésicos
Vías de Administración de Medicamentos
Farmacopea Brasileña
description The aims of this work are obtaining and evaluating paracetamol oral suspension 32 mg/mL by qualitative and quantitative planning of the ingredients. The observations of the physical-chemical formulations were based in comparison with the specifications of paracetamol solution contained in the Brazilian Pharmacopoeia and editing with some analysis on the same reference drug (Tylenol® child 32 mg / mL). We sought to develop a low cost and good quality formulation, acceptable to the children's market, since the suspension dosage form is characterized by disguising the unpleasant taste of drugs. The chosen formulation showed good rheology properties, excellent sensory and values of pH, viscosity, density and content within the pharmacopoeia specifications. We obtained a satisfactory formulation, with smaller amount of excipients in relation to the reference product, which can be used by diabetics and is compatible with the official specifications, with respect to physical-chemical tests performed.
format Articulo
Articulo
author Silva, Felícia P. S.
Soares, Janete S.
Rolim, Larissa A.
Lyra, Magalí A. M. de
Silva, Keyla E.R. da
Silva, Rosali M. F. da
Rolim Neto, Pedró José
author_facet Silva, Felícia P. S.
Soares, Janete S.
Rolim, Larissa A.
Lyra, Magalí A. M. de
Silva, Keyla E.R. da
Silva, Rosali M. F. da
Rolim Neto, Pedró José
author_sort Silva, Felícia P. S.
title Pharmaceutical development of paracetamol oral suspension
title_short Pharmaceutical development of paracetamol oral suspension
title_full Pharmaceutical development of paracetamol oral suspension
title_fullStr Pharmaceutical development of paracetamol oral suspension
title_full_unstemmed Pharmaceutical development of paracetamol oral suspension
title_sort pharmaceutical development of paracetamol oral suspension
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8337
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_15.pdf
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