A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells
The degree of similarity between chemical and physical agents in their capacity to induce reciprocal translocations was analyzed by means of multivariate analysis techniques. The effect of three different doses of gamma rays, four doses of X-rays and different doses of adriamycin, mitomycin C, thio-...
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2000
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/83364 |
| Aporte de: |
| id |
I19-R120-10915-83364 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Veterinarias multivariate analysis similarity reciprocal translocations |
| spellingShingle |
Ciencias Veterinarias multivariate analysis similarity reciprocal translocations De Luca, Julio César Ortiz Jaureguizar, Edgardo Dulout, Fernando Noel A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| topic_facet |
Ciencias Veterinarias multivariate analysis similarity reciprocal translocations |
| description |
The degree of similarity between chemical and physical agents in their capacity to induce reciprocal translocations was analyzed by means of multivariate analysis techniques. The effect of three different doses of gamma rays, four doses of X-rays and different doses of adriamycin, mitomycin C, thio-tepa and bleomycin was analyzed. Data were arranged in a basic matrix by two methods: cluster analysis and ordination. Two main groups were found, one including doses of 9 and 10 Gy and the other including the remaining lower doses of ionizing radiation and the other chemicals. Various subgroups were found within the second group. Accordingly, using presence/absence data there was not a specific pattern of chromosomal damage induction for physical and chemical agents. The increase in the frequencies of reciprocal translocation observed with 9 and 10 Gy was due to an increase in the kind of multivalent configurations. This variability could be dose dependent. Likewise, the similarity observed in the second group between the chemicals and the lower doses of ionizing radiation could also be dose dependent. |
| format |
Articulo Articulo |
| author |
De Luca, Julio César Ortiz Jaureguizar, Edgardo Dulout, Fernando Noel |
| author_facet |
De Luca, Julio César Ortiz Jaureguizar, Edgardo Dulout, Fernando Noel |
| author_sort |
De Luca, Julio César |
| title |
A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| title_short |
A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| title_full |
A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| title_fullStr |
A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| title_full_unstemmed |
A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| title_sort |
multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells |
| publishDate |
2000 |
| url |
http://sedici.unlp.edu.ar/handle/10915/83364 |
| work_keys_str_mv |
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Repositorios |
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1764820488546156544 |