Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity

Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic a...

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Detalles Bibliográficos
Autores principales: van Baren, Catalina, Martino, Virginia S., Di Leo Lira, Paola, Anao, Ivie, Houghton, Peter, Debenedetti, Silvia Laura, Croft, Simon
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Farmacia
Antiprotozoal Compounds
Satureja parvifolia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83257
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83257
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Antiprotozoal Compounds
Satureja parvifolia
spellingShingle Farmacia
Antiprotozoal Compounds
Satureja parvifolia
van Baren, Catalina
Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
topic_facet Farmacia
Antiprotozoal Compounds
Satureja parvifolia
description Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9,Mg/ml, luteolin 6.4,μg/ml, oleanolic acid 9.3,μg/ml and eriodictyol 17.2,μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2,μg/ml) on the mammalian KB cell line.
format Articulo
Articulo
author van Baren, Catalina
Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
author_facet van Baren, Catalina
Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
author_sort van Baren, Catalina
title Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_short Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_full Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_fullStr Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_full_unstemmed Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_sort triterpenic acids and flavonoids from satureja parvifolia: evaluation of their antiprotozoal activity
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/83257
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