Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method

Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) were prepared by emulsion solvent diffusion (ESD) method using acetone, water and...

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Detalles Bibliográficos
Autores principales:	Tapas, Amit R., Kawtikwar, Pravin S., Sakarkar, Dinesh M.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia carvedilol; cyclodextrins; spherical crystallization; emulsion solvent diffusion method
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8324 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8324
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia carvedilol; cyclodextrins; spherical crystallization; emulsion solvent diffusion method
spellingShingle	Farmacia carvedilol; cyclodextrins; spherical crystallization; emulsion solvent diffusion method Tapas, Amit R. Kawtikwar, Pravin S. Sakarkar, Dinesh M. Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
topic_facet	Farmacia carvedilol; cyclodextrins; spherical crystallization; emulsion solvent diffusion method
description	Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) were prepared by emulsion solvent diffusion (ESD) method using acetone, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. Agglomerates were prepared by using β-cyclodextrin and hydroxy propyl-β-cyclodextrin as a hydrophilic polymers. The agglomerates were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) and were evaluated for flowability, solubility and drug release. CAR agglomerates exhibited significantly improved micromeritic properties, solubility as well as dissolution behaviors in comparison with pure CAR crystals. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol.
format	Articulo Articulo
author	Tapas, Amit R. Kawtikwar, Pravin S. Sakarkar, Dinesh M.
author_facet	Tapas, Amit R. Kawtikwar, Pravin S. Sakarkar, Dinesh M.
author_sort	Tapas, Amit R.
title	Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
title_short	Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
title_full	Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
title_fullStr	Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
title_full_unstemmed	Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
title_sort	evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8324 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_1.pdf
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bdutipo_str	Repositorios
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Evaluation of physico-mechanical properties of carvedilol-cyclodextrin agglomerates obtained by emulsion solvent diffusion method

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