Electroanalytical characterization of 4-nerolidylcatechol and its derivatives

4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising analgesic, anti-inflammatory and antimicrobial activity. However, low water solubi...

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Detalles Bibliográficos
Autores principales:	Leal, Ana Flávia V. B., Rezende, Kênnia R., Gil, Éric S.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia antioxidant; cyclodextrins; electrochemical, 4-nerolidylcatechol; silanized derivatives; voltammetry Agentes Protectores Solubilidad Técnicas Electroquímicas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8320 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8320
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antioxidant; cyclodextrins; electrochemical, 4-nerolidylcatechol; silanized derivatives; voltammetry Agentes Protectores Solubilidad Técnicas Electroquímicas
spellingShingle	Farmacia antioxidant; cyclodextrins; electrochemical, 4-nerolidylcatechol; silanized derivatives; voltammetry Agentes Protectores Solubilidad Técnicas Electroquímicas Leal, Ana Flávia V. B. Rezende, Kênnia R. Gil, Éric S. Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
topic_facet	Farmacia antioxidant; cyclodextrins; electrochemical, 4-nerolidylcatechol; silanized derivatives; voltammetry Agentes Protectores Solubilidad Técnicas Electroquímicas
description	4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising analgesic, anti-inflammatory and antimicrobial activity. However, low water solubility and chemical instability has limited its use and analysis. Therefore, chemical modifications such as silylated derivatives and inclusion complexes have been proposed. Regarding antioxidants, electrochemical investigation techniques are important tools in comprehensive characterization of phenol molecules, showing higher selectivity than spectroscopic methods. In the present study, the 4-NRC and its derivatives are characterizated by voltammetric analysis in order to support physicochemical properties of 4-NRC inclusion-complex and catechol silylation products. It is observed that in both liquid- or solid-state the redox process of the 4-NRC is non-reversible and occurs in two stages, seen as two anodic peaks, respectively, at 0.75 and 1.12 V. The electrochemical techniques showed to be also a powerful tool to evaluate the efficiency of chemical modification on electroactive groups.
format	Articulo Comunicacion
author	Leal, Ana Flávia V. B. Rezende, Kênnia R. Gil, Éric S.
author_facet	Leal, Ana Flávia V. B. Rezende, Kênnia R. Gil, Éric S.
author_sort	Leal, Ana Flávia V. B.
title	Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
title_short	Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
title_full	Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
title_fullStr	Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
title_full_unstemmed	Electroanalytical characterization of 4-nerolidylcatechol and its derivatives
title_sort	electroanalytical characterization of 4-nerolidylcatechol and its derivatives
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8320 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_5.pdf
work_keys_str_mv	AT lealanaflaviavb electroanalyticalcharacterizationof4nerolidylcatecholanditsderivatives AT rezendekenniar electroanalyticalcharacterizationof4nerolidylcatecholanditsderivatives AT gilerics electroanalyticalcharacterizationof4nerolidylcatecholanditsderivatives
bdutipo_str	Repositorios
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Electroanalytical characterization of 4-nerolidylcatechol and its derivatives

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