Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa

Novel stable mucoadhesive chitosan microspheres were developed to explore the possibility of nasal delivery of L-dopa to avoid first pass metabolism and to improve therapeutic efficiency in treating the symptoms of parkinsonism. The mucoadhesive microspheres were prepared by spray drying using 23 fu...

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Detalles Bibliográficos
Autores principales: Ghodke, Dhananjay S., Naikwade, Nilofar S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
factorial design; L-Dopa; nasal drug delivery
Vías de Administración de Medicamentos
Quitosana
Microesferas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8315
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_26.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8315
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
factorial design; L-Dopa; nasal drug delivery
Vías de Administración de Medicamentos
Quitosana
Microesferas
spellingShingle Farmacia
factorial design; L-Dopa; nasal drug delivery
Vías de Administración de Medicamentos
Quitosana
Microesferas
Ghodke, Dhananjay S.
Naikwade, Nilofar S.
Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
topic_facet Farmacia
factorial design; L-Dopa; nasal drug delivery
Vías de Administración de Medicamentos
Quitosana
Microesferas
description Novel stable mucoadhesive chitosan microspheres were developed to explore the possibility of nasal delivery of L-dopa to avoid first pass metabolism and to improve therapeutic efficiency in treating the symptoms of parkinsonism. The mucoadhesive microspheres were prepared by spray drying using 23 full factorial design with inlet temperature (A), liquid feed flow rate (B), and drug to polymer concentration (C) as independent variable. Then microspheres were characterized in terms of morphology (Scanning Electron Microscopy, SEM), drug content, production yield, particle size and thermal behavior (Differential Scanning Calorimetry (DSC) and mucoadhesion test. In vitro drug release studies were performed in simulated nasal electrolyte fluid. Factorial design results indicated that main effect of factor A alone has significant effect on moisture content whereas AC had effect on moisture content. Microspheres containing moisture below 11 % were found to be stable. Treatment of in vitro data to mathematical model of different kinetic equations indicated that drug release from the microspheres was best characterized by the Korsmeyer-Peppas model. The results of DSC studies revealed molecular amorphous dispersion of Ldopa into the chitosan microspheres. Stability studies showed that microspheres were stable over a period of three months.
format Articulo
Articulo
author Ghodke, Dhananjay S.
Naikwade, Nilofar S.
author_facet Ghodke, Dhananjay S.
Naikwade, Nilofar S.
author_sort Ghodke, Dhananjay S.
title Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
title_short Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
title_full Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
title_fullStr Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
title_full_unstemmed Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa
title_sort preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of l-dopa
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8315
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_26.pdf
work_keys_str_mv AT ghodkedhananjays preparationcharacterizationandinvitroevaluationofstablemucoadhesiveintranasalmicrosphereofldopa
AT naikwadenilofars preparationcharacterizationandinvitroevaluationofstablemucoadhesiveintranasalmicrosphereofldopa
bdutipo_str Repositorios
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