Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells

Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial...

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Autores principales: Pérez Vidakovics, María Laura Anabella, Lamberti, Yanina Andrea, Serra, Diego, Berbers, Guy A. M., Pol, W. Ludo van der, Rodríguez, María Eugenia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2007
Materias:
Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83149
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83149
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
spellingShingle Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
Pérez Vidakovics, María Laura Anabella
Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
topic_facet Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
description Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.
format Articulo
Articulo
author Pérez Vidakovics, María Laura Anabella
Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
author_facet Pérez Vidakovics, María Laura Anabella
Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
author_sort Pérez Vidakovics, María Laura Anabella
title Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_short Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_full Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_fullStr Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_full_unstemmed Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_sort iron stress increases bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/83149
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