Geographic patterns of genome admixture in latin American mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixt...

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Detalles Bibliográficos
Autores principales: Bailliet, Graciela, Bianchi, Néstor Oscar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Biología
Antropología
Genética
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83047
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83047
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Antropología
Genética
spellingShingle Biología
Antropología
Genética
Bailliet, Graciela
Bianchi, Néstor Oscar
Geographic patterns of genome admixture in latin American mestizos
topic_facet Biología
Antropología
Genética
description The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.
format Articulo
Articulo
author Bailliet, Graciela
Bianchi, Néstor Oscar
author_facet Bailliet, Graciela
Bianchi, Néstor Oscar
author_sort Bailliet, Graciela
title Geographic patterns of genome admixture in latin American mestizos
title_short Geographic patterns of genome admixture in latin American mestizos
title_full Geographic patterns of genome admixture in latin American mestizos
title_fullStr Geographic patterns of genome admixture in latin American mestizos
title_full_unstemmed Geographic patterns of genome admixture in latin American mestizos
title_sort geographic patterns of genome admixture in latin american mestizos
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/83047
work_keys_str_mv AT baillietgraciela geographicpatternsofgenomeadmixtureinlatinamericanmestizos
AT bianchinestoroscar geographicpatternsofgenomeadmixtureinlatinamericanmestizos
bdutipo_str Repositorios
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