Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system
In the present study, mucilage from leaves of Hibiscus rosa-sinensis L. was extracted and physico-chemical parameters like swelling ratio and angle of repose were determined. Diclofenac sodium matrix tablets containing dried mucilage of H. rosa-sinensis were prepared by direct compression (hydrophil...
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8295 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_5.pdf |
| Aporte de: |
| id |
I19-R120-10915-8295 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Hibiscus diclofenac sodium; hibiscus rosa-sinensis L.; in vitro drug release; water uptake and mass loss Fenilacetatos Extractos Vegetales |
| spellingShingle |
Farmacia Hibiscus diclofenac sodium; hibiscus rosa-sinensis L.; in vitro drug release; water uptake and mass loss Fenilacetatos Extractos Vegetales Shah, Dhiren P. Jani, Girish K. Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| topic_facet |
Farmacia Hibiscus diclofenac sodium; hibiscus rosa-sinensis L.; in vitro drug release; water uptake and mass loss Fenilacetatos Extractos Vegetales |
| description |
In the present study, mucilage from leaves of Hibiscus rosa-sinensis L. was extracted and physico-chemical parameters like swelling ratio and angle of repose were determined. Diclofenac sodium matrix tablets containing dried mucilage of H. rosa-sinensis were prepared by direct compression (hydrophilic and hydrophobic). Level and type of excipients influence on drug release, as well as water uptake and mass loss studies were carried out. Stability study of tablets was carried out at 40 °C and 75 % RH for three months. The dried mucilage powder shows superior swelling in all three different media. Batches H and N full fills the entire set criterion. Drug release kinetics from these formulations corresponded best to the zero-order kinetics. There was no significant effect of agitation speed on water uptake while mass loss was significantly affected by agitation speeds of prepared tablets. Tablets are stable after storage. |
| format |
Articulo Articulo |
| author |
Shah, Dhiren P. Jani, Girish K. |
| author_facet |
Shah, Dhiren P. Jani, Girish K. |
| author_sort |
Shah, Dhiren P. |
| title |
Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| title_short |
Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| title_full |
Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| title_fullStr |
Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| title_full_unstemmed |
Influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| title_sort |
influence of excipient type and level on quality control parameters of tablets formulated from polysaccharides matrix system |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8295 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_5.pdf |
| work_keys_str_mv |
AT shahdhirenp influenceofexcipienttypeandlevelonqualitycontrolparametersoftabletsformulatedfrompolysaccharidesmatrixsystem AT janigirishk influenceofexcipienttypeandlevelonqualitycontrolparametersoftabletsformulatedfrompolysaccharidesmatrixsystem |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488091074562 |