Development and evaluation of carvedilol/ polyethylene oxide matrix tablets

Hydrophilic matrix tablets were developed with carvedilol (CRV), using different molecular weights of polyethylene oxide (PEO). Investigations were carried out in order to verify the tablets performance. All formulations satisfied the official requirements. Water uptake studies were influenced by pH...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Barboza, Fernanda M., Stulzer, Hellen Karine
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
carvedilol; matrix tablets; polyethylene oxide; release behavior
Receptores beta Adrenérgicos
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8281
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_23.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8281
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
carvedilol; matrix tablets; polyethylene oxide; release behavior
Receptores beta Adrenérgicos
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
carvedilol; matrix tablets; polyethylene oxide; release behavior
Receptores beta Adrenérgicos
Sistemas de Liberación de Medicamentos
Barboza, Fernanda M.
Stulzer, Hellen Karine
Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
topic_facet Farmacia
carvedilol; matrix tablets; polyethylene oxide; release behavior
Receptores beta Adrenérgicos
Sistemas de Liberación de Medicamentos
description Hydrophilic matrix tablets were developed with carvedilol (CRV), using different molecular weights of polyethylene oxide (PEO). Investigations were carried out in order to verify the tablets performance. All formulations satisfied the official requirements. Water uptake studies were influenced by pH value and polymer concentration. CRV release was sustained for 23 and 19 h, in acid and neutral conditions, respectively. The mechanism involved in drug release was characterized by anomalous behavior for all formulations in phosphate buffer whereas in acid conditions they presented a Fickian kinetics, Case II transport and Super Case II transport kinetics for different formulations.
format Articulo
Articulo
author Barboza, Fernanda M.
Stulzer, Hellen Karine
author_facet Barboza, Fernanda M.
Stulzer, Hellen Karine
author_sort Barboza, Fernanda M.
title Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
title_short Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
title_full Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
title_fullStr Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
title_full_unstemmed Development and evaluation of carvedilol/ polyethylene oxide matrix tablets
title_sort development and evaluation of carvedilol/ polyethylene oxide matrix tablets
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8281
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_23.pdf
work_keys_str_mv AT barbozafernandam developmentandevaluationofcarvedilolpolyethyleneoxidematrixtablets
AT stulzerhellenkarine developmentandevaluationofcarvedilolpolyethyleneoxidematrixtablets
bdutipo_str Repositorios
_version_ 1764820488647868418

Ejemplares similares