Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"

Pokreisz et al. recently published an interesting article in which they show increased cardiac left ventricular phosphodiesterase-5A (PDE5A) expression in patients with heart failure. They also generated a PDE5A transgenic mouse in which overexpression of this cGMP-selective phosphodiesterase worsen...

Descripción completa

Detalles Bibliográficos
Autores principales: Cingolani, Oscar H., Pérez, Néstor Gustavo, Cingolani, Horacio Eugenio
Formato: Articulo Contribucion a revista
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Médicas
Carta
Enfermedad cardiovascular
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/82784
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-82784
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Carta
Enfermedad cardiovascular
spellingShingle Ciencias Médicas
Carta
Enfermedad cardiovascular
Cingolani, Oscar H.
Pérez, Néstor Gustavo
Cingolani, Horacio Eugenio
Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
topic_facet Ciencias Médicas
Carta
Enfermedad cardiovascular
description Pokreisz et al. recently published an interesting article in which they show increased cardiac left ventricular phosphodiesterase-5A (PDE5A) expression in patients with heart failure. They also generated a PDE5A transgenic mouse in which overexpression of this cGMP-selective phosphodiesterase worsened ventricular remodeling and function after myocardial infarction. Therefore, the obvious conclusion seems to be that inhibition of PDE5A might protect against postmyocardial infarction remodeling. Although the authors show cGMP to be related to these cardiac architectural changes, they raise new questions about the possible cGMP downstream signaling mechanisms involved.
format Articulo
Contribucion a revista
author Cingolani, Oscar H.
Pérez, Néstor Gustavo
Cingolani, Horacio Eugenio
author_facet Cingolani, Oscar H.
Pérez, Néstor Gustavo
Cingolani, Horacio Eugenio
author_sort Cingolani, Oscar H.
title Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
title_short Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
title_full Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
title_fullStr Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
title_full_unstemmed Letter by Cingolani et al. regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
title_sort letter by cingolani et al. regarding article, "ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice"
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/82784
work_keys_str_mv AT cingolanioscarh letterbycingolanietalregardingarticleventricularphosphodiesterase5expressionisincreasedinpatientswithadvancedheartfailureandcontributestoadverseventricularremodelingaftermyocardialinfarctioninmice
AT pereznestorgustavo letterbycingolanietalregardingarticleventricularphosphodiesterase5expressionisincreasedinpatientswithadvancedheartfailureandcontributestoadverseventricularremodelingaftermyocardialinfarctioninmice
AT cingolanihoracioeugenio letterbycingolanietalregardingarticleventricularphosphodiesterase5expressionisincreasedinpatientswithadvancedheartfailureandcontributestoadverseventricularremodelingaftermyocardialinfarctioninmice
bdutipo_str Repositorios
_version_ 1764820488624799746

Ejemplares similares