Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8275 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_17.pdf |
| Aporte de: |
| id |
I19-R120-10915-8275 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia captopril; charge transfer complex; chemometric methods; pharmaceuticals formulations Aminoácidos Espectrofotometría |
| spellingShingle |
Farmacia captopril; charge transfer complex; chemometric methods; pharmaceuticals formulations Aminoácidos Espectrofotometría Ribeiro, Paulo R. S.. Pezza, Leonardo Pezza, Helena Tognolli, João O. Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| topic_facet |
Farmacia captopril; charge transfer complex; chemometric methods; pharmaceuticals formulations Aminoácidos Espectrofotometría |
| description |
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized using chemometric methods of fractional factorial and central composite design. At the optimum reaction conditions, the rectilinear calibration graphs were obtained in the concentration range 1.86 x 10<sup>-4</sup> to 7.38 x 10<sup>-4</sup> mol/L captopril with an excellent correlation coefficient (r = 0.9996). The proposed procedure could be applied successfully for the determination of the investigated drug in their pharmaceutical dosage forms with a good precision and accuracy compared to official and reported method as revealed by F- and t-tests at 95 % confidence level. No interference was observed from common excipients in formulations. |
| format |
Articulo Articulo |
| author |
Ribeiro, Paulo R. S.. Pezza, Leonardo Pezza, Helena Tognolli, João O. |
| author_facet |
Ribeiro, Paulo R. S.. Pezza, Leonardo Pezza, Helena Tognolli, João O. |
| author_sort |
Ribeiro, Paulo R. S.. |
| title |
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| title_short |
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| title_full |
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| title_fullStr |
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| title_full_unstemmed |
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| title_sort |
spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8275 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_17.pdf |
| work_keys_str_mv |
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Repositorios |
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1764820488590196741 |