In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system

Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap papain into a polymeric matrix to provide an adequate drug delivery system consist...

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Autores principales: Alcântara, Mara T. S., Velasco, María Valéria R., Zulli, Gislaine, Lopes, Patrícia S., Miyamaru, Lígia L., Bárbara, Maria C.S., Rogero, Suize O., Lugão, Ademar B., Mathor, Monica B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
cutaneous irritation test; cytotoxicity test; drug delivery system; papain
Enzimas
Pruebas de Toxicidad
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8268
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_10.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8268
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
cutaneous irritation test; cytotoxicity test; drug delivery system; papain
Enzimas
Pruebas de Toxicidad
spellingShingle Farmacia
cutaneous irritation test; cytotoxicity test; drug delivery system; papain
Enzimas
Pruebas de Toxicidad
Alcântara, Mara T. S.
Velasco, María Valéria R.
Zulli, Gislaine
Lopes, Patrícia S.
Miyamaru, Lígia L.
Bárbara, Maria C.S.
Rogero, Suize O.
Lugão, Ademar B.
Mathor, Monica B.
In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
topic_facet Farmacia
cutaneous irritation test; cytotoxicity test; drug delivery system; papain
Enzimas
Pruebas de Toxicidad
description Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap papain into a polymeric matrix to provide an adequate drug delivery system consists of an alternative to this problem. The purpose of this study was to assess in vitro and in vivo four polymers cytotoxicity and ability to cause cutaneous irritation to be applied as a suitable papain delivery system. A Monocomponent (MSD) and Bicomponent Silicone Dispersions (BSD) and, Natural Rubber Bicentrifuged Latex (NRBL) and an Acrylic Adhesive (AA) were selected. The cytotoxicity was firstly assessed by the Neutral Red Uptake Method. Non-cytotoxic polymers were then submitted to in vivo Cutaneous Irritation Test. Both silicone dispersions were found non-cytotoxic, and NRBL and AA polymers showed cytotoxicity. MSD and BSD polymers did not cause any cutaneous reactions.
format Articulo
Articulo
author Alcântara, Mara T. S.
Velasco, María Valéria R.
Zulli, Gislaine
Lopes, Patrícia S.
Miyamaru, Lígia L.
Bárbara, Maria C.S.
Rogero, Suize O.
Lugão, Ademar B.
Mathor, Monica B.
author_facet Alcântara, Mara T. S.
Velasco, María Valéria R.
Zulli, Gislaine
Lopes, Patrícia S.
Miyamaru, Lígia L.
Bárbara, Maria C.S.
Rogero, Suize O.
Lugão, Ademar B.
Mathor, Monica B.
author_sort Alcântara, Mara T. S.
title In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
title_short In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
title_full In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
title_fullStr In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
title_full_unstemmed In vitro and In vivo toxicology evaluation to determine suitable biomedical Polymers for development of a papain-containing drug delivery system
title_sort in vitro and in vivo toxicology evaluation to determine suitable biomedical polymers for development of a papain-containing drug delivery system
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8268
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_10.pdf
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