In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates
Fluorouracil acetic acid–dextran (FUD) conjugates were synthesized and its stability in buffer solution has been investigated previously in our laboratory. In this contribution, the in vitro and in vivo releases of FUD were investigated. The results revealed that no detectable 5-fluorouracil (5-FU,...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8245 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_21.pdf |
| Aporte de: |
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I19-R120-10915-8245 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia colon specific; dextran conjugates; fluorouracil; macromolecular prodrug Prodrogas Técnicas y Procedimientos de Laboratorio Portadores de Fármacos |
| spellingShingle |
Farmacia colon specific; dextran conjugates; fluorouracil; macromolecular prodrug Prodrogas Técnicas y Procedimientos de Laboratorio Portadores de Fármacos Hao, Aijun Deng, Yingjie Chen, Changlan Zheng, Ying Chen, Lijiang In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| topic_facet |
Farmacia colon specific; dextran conjugates; fluorouracil; macromolecular prodrug Prodrogas Técnicas y Procedimientos de Laboratorio Portadores de Fármacos |
| description |
Fluorouracil acetic acid–dextran (FUD) conjugates were synthesized and its stability in buffer solution has been investigated previously in our laboratory. In this contribution, the in vitro and in vivo releases of FUD were investigated. The results revealed that no detectable 5-fluorouracil (5-FU, FU) found during in vitro and in vivo release studies. The in vitro release was dependent on both degree of substitution (DS) of 5-fluorouracil-1-acetic acid (5-FUA) in FUD and gastrointestinal tract section (GITs). 5- FUA can be completely released from the conjugates with DS of 10.3 % (wt/wt) in homogenates of cecum and colon content. After oral administration in rats, FUD with DS of 10.3 % showed colon specific delivery of 5-FUA compared with that of free 5-FUA. The target index (TI) of the conjugate was 1.93 in cecum contents and 2.09 in colon contents respectively within 24 h. The results indicated that the conjugates can be used as colon-specific delivery system of 5-FUA. |
| format |
Articulo Articulo |
| author |
Hao, Aijun Deng, Yingjie Chen, Changlan Zheng, Ying Chen, Lijiang |
| author_facet |
Hao, Aijun Deng, Yingjie Chen, Changlan Zheng, Ying Chen, Lijiang |
| author_sort |
Hao, Aijun |
| title |
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| title_short |
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| title_full |
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| title_fullStr |
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| title_full_unstemmed |
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| title_sort |
in vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8245 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_21.pdf |
| work_keys_str_mv |
AT haoaijun invitroandinvivoreleasestudiesoffluorouracilaceticaciddextranconjugates AT dengyingjie invitroandinvivoreleasestudiesoffluorouracilaceticaciddextranconjugates AT chenchanglan invitroandinvivoreleasestudiesoffluorouracilaceticaciddextranconjugates AT zhengying invitroandinvivoreleasestudiesoffluorouracilaceticaciddextranconjugates AT chenlijiang invitroandinvivoreleasestudiesoffluorouracilaceticaciddextranconjugates |
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Repositorios |
| _version_ |
1764820488292401158 |