Release behavior and bioadhesivity of a hydrophobic polyacid gel

The release behavior of salicylic acid and the bioadhesion properties of crosslinked polyacid hydrophobic-gel disks, containing methyl methacrylate-co-methacrylic acid, were evaluated in simulated fluids. In gastric fluid a very low amount of drug was released with a minimal swelling and water uptak...

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Detalles Bibliográficos
Autores principales: Cornejo-Bravo, José M., Ganem-Quintanar, Adriana, Piñón-Segundo, Elizabeth, Serrano-Medina, Aracely, Quintanar-Guerrero, David
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
bioadhesion; controlled release; hydrogels; hydrophobic polyacid gels
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8244
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_20.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8244
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
bioadhesion; controlled release; hydrogels; hydrophobic polyacid gels
spellingShingle Farmacia
bioadhesion; controlled release; hydrogels; hydrophobic polyacid gels
Cornejo-Bravo, José M.
Ganem-Quintanar, Adriana
Piñón-Segundo, Elizabeth
Serrano-Medina, Aracely
Quintanar-Guerrero, David
Release behavior and bioadhesivity of a hydrophobic polyacid gel
topic_facet Farmacia
bioadhesion; controlled release; hydrogels; hydrophobic polyacid gels
description The release behavior of salicylic acid and the bioadhesion properties of crosslinked polyacid hydrophobic-gel disks, containing methyl methacrylate-co-methacrylic acid, were evaluated in simulated fluids. In gastric fluid a very low amount of drug was released with a minimal swelling and water uptake. The drug release was dependent of the drug precipitated in the interconnecting micropores of the disk structure. The transport and release type in this medium ranged from Fickian to zero order depending of drug loading. In intestinal fluid, disks swelled completely and the water absorption capacity was eight-fold its dry weight. In this case the released drug showed a biphasic behavior with a fast linear release (Mt /Mα ≤ 0.6), followed by a slow drug release controlled by the gel swelling. Bioadhesion was measured by the tensiometer method on pig mucosae, the results indicated that these polyacid hydrogels are weak bioadhesives on both gastric and intestinal mucosae.
format Articulo
Articulo
author Cornejo-Bravo, José M.
Ganem-Quintanar, Adriana
Piñón-Segundo, Elizabeth
Serrano-Medina, Aracely
Quintanar-Guerrero, David
author_facet Cornejo-Bravo, José M.
Ganem-Quintanar, Adriana
Piñón-Segundo, Elizabeth
Serrano-Medina, Aracely
Quintanar-Guerrero, David
author_sort Cornejo-Bravo, José M.
title Release behavior and bioadhesivity of a hydrophobic polyacid gel
title_short Release behavior and bioadhesivity of a hydrophobic polyacid gel
title_full Release behavior and bioadhesivity of a hydrophobic polyacid gel
title_fullStr Release behavior and bioadhesivity of a hydrophobic polyacid gel
title_full_unstemmed Release behavior and bioadhesivity of a hydrophobic polyacid gel
title_sort release behavior and bioadhesivity of a hydrophobic polyacid gel
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8244
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_20.pdf
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