Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium

This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model drug molecule for intestinal drug prolonged release. Diclofenac loaded HPMC-SA bea...

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Detalles Bibliográficos
Autores principales: Ray, Sarbani D., Ghosal, Kajal, Ghosal, Ingana, Ghosh, Dipanwita
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Sistemas de Liberación de Medicamentos
beads; diclofenac; hydrophobic HPMC; sodium alginate; swelling
Metilcelulosa
Éteres
Diclofenaco
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8241
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_17.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8241
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Sistemas de Liberación de Medicamentos
beads; diclofenac; hydrophobic HPMC; sodium alginate; swelling
Metilcelulosa
Éteres
Diclofenaco
spellingShingle Farmacia
Sistemas de Liberación de Medicamentos
beads; diclofenac; hydrophobic HPMC; sodium alginate; swelling
Metilcelulosa
Éteres
Diclofenaco
Ray, Sarbani D.
Ghosal, Kajal
Ghosal, Ingana
Ghosh, Dipanwita
Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
topic_facet Farmacia
Sistemas de Liberación de Medicamentos
beads; diclofenac; hydrophobic HPMC; sodium alginate; swelling
Metilcelulosa
Éteres
Diclofenaco
description This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model drug molecule for intestinal drug prolonged release. Diclofenac loaded HPMC-SA beads have been developed by ion exchange methods and were characterized by encapsulation efficiency, drug release profile, swelling and matrix erosion rate. Matrix swelling of calcium alginate beads induced by phosphate buffer ends up in erosion and destruction. However, for HPMC-SA beads do not lead to complete erosion, which may be the main cause of diclofenac retention within the matrix. The release of diclofenac potassium is negligible at acidic pH, while is complete in 5-6 h when pH is raised up to 7.4. The alginate/HPMC ratio controls the release rate of the drug. The drug release is decreased as the polymer concentration is increased from 2.5 to 3.5 %. Release kinetic study was done to understand the correlation between the formulations. The results show that drug release is diffusion controlled and it is Anomalous type which means combined process of both swelling and erosion of polymer.
format Articulo
Articulo
author Ray, Sarbani D.
Ghosal, Kajal
Ghosal, Ingana
Ghosh, Dipanwita
author_facet Ray, Sarbani D.
Ghosal, Kajal
Ghosal, Ingana
Ghosh, Dipanwita
author_sort Ray, Sarbani D.
title Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
title_short Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
title_full Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
title_fullStr Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
title_full_unstemmed Alginate/hydrophobic HPMC (60L) particulate systems: new matrix for controlled release of diclofenac potassium
title_sort alginate/hydrophobic hpmc (60l) particulate systems: new matrix for controlled release of diclofenac potassium
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8241
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_17.pdf
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AT ghosalkajal alginatehydrophobichpmc60lparticulatesystemsnewmatrixforcontrolledreleaseofdiclofenacpotassium
AT ghosalingana alginatehydrophobichpmc60lparticulatesystemsnewmatrixforcontrolledreleaseofdiclofenacpotassium
AT ghoshdipanwita alginatehydrophobichpmc60lparticulatesystemsnewmatrixforcontrolledreleaseofdiclofenacpotassium
bdutipo_str Repositorios
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