Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
This study examined the effects of enalapril treatment on L-NAME-induced hypertensive rats and oxidative profile in the heart. Four experimental groups were established: control (received water for three weeks); L-NAME (600 mg/L in drinking for three weeks); enalapril (20 mg/L in drinking two last w...
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Formato: | Articulo |
Lenguaje: | Inglés |
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2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8236 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_12.pdf |
Aporte de: |
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I19-R120-10915-8236 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Enfermedades Cardiovasculares antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide Inhibidores de la Enzima Convertidora de Angiotensina |
spellingShingle |
Farmacia Enfermedades Cardiovasculares antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide Inhibidores de la Enzima Convertidora de Angiotensina Bock, Patrícia M. Araujo, Alex S. R. Belló Klein, Adriane Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
topic_facet |
Farmacia Enfermedades Cardiovasculares antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide Inhibidores de la Enzima Convertidora de Angiotensina |
description |
This study examined the effects of enalapril treatment on L-NAME-induced hypertensive rats and oxidative profile in the heart. Four experimental groups were established: control (received water for three weeks); L-NAME (600 mg/L in drinking for three weeks); enalapril (20 mg/L in drinking two last weeks); L-NAME + enalapril, treated with L-NAME for one week, and L-NAME plus enalapril in the last two weeks. Arterial blood pressure, lipid peroxidation (TBARS and chemiluminescence-CL), and catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase activities were evaluated. An increase by 47 % in the arterial blood pressure was observed in L-NAME-treated rats. Hypertension was reduced (9 %) with enalapril. Hypertension increased TBARS (177 %), CL (23 %), and glutathione peroxidase (31 %), this last, reducing by 11 % in L-NAME + enalapril group. Glutathione-Stransferase increased by 46 % in enalapril group. These results suggest that L-NAME administration increased arterial pressure and oxidative stress, indicating glutathione peroxidase as an important antioxidant in this model. |
format |
Articulo Articulo |
author |
Bock, Patrícia M. Araujo, Alex S. R. Belló Klein, Adriane |
author_facet |
Bock, Patrícia M. Araujo, Alex S. R. Belló Klein, Adriane |
author_sort |
Bock, Patrícia M. |
title |
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
title_short |
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
title_full |
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
title_fullStr |
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
title_full_unstemmed |
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
title_sort |
enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/8236 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_12.pdf |
work_keys_str_mv |
AT bockpatriciam enalaprileffectsonnitricoxidesynthaseinhibitioninducedhypertensionhemodynamicandoxidativestressevaluations AT araujoalexsr enalaprileffectsonnitricoxidesynthaseinhibitioninducedhypertensionhemodynamicandoxidativestressevaluations AT bellokleinadriane enalaprileffectsonnitricoxidesynthaseinhibitioninducedhypertensionhemodynamicandoxidativestressevaluations |
bdutipo_str |
Repositorios |
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1764820488202223616 |