Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol

The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, dissolution rate and ultimately, oral bioavailability of CDL. The solubility of CDL w...

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Detalles Bibliográficos
Autores principales: Rao, Monica, Munjapara, Ghanshyam S., Khole, Ishwar A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
carvedilol; polyethylene glycol 400; capmul MCM C8
Sistemas de Liberación de Medicamentos
Formas de Dosificación
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8225
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8225
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
carvedilol; polyethylene glycol 400; capmul MCM C8
Sistemas de Liberación de Medicamentos
Formas de Dosificación
spellingShingle Farmacia
carvedilol; polyethylene glycol 400; capmul MCM C8
Sistemas de Liberación de Medicamentos
Formas de Dosificación
Rao, Monica
Munjapara, Ghanshyam S.
Khole, Ishwar A.
Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
topic_facet Farmacia
carvedilol; polyethylene glycol 400; capmul MCM C8
Sistemas de Liberación de Medicamentos
Formas de Dosificación
description The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, dissolution rate and ultimately, oral bioavailability of CDL. The solubility of CDL was determined in various oils, surfactants and cosolvents. Pseudoternary phase diagrams were used to identify the region of microemulsification. The SMEDDS were characterized by morphological observation, droplet size and zeta-potential, cloud point, % transmission study and emulsification time. The optimized formulation was composed of Capmul MCM C8 (18 %), Tween 80 (65.6 %), and polyethylene glycol 400 (14.4 %). The SMEDDS formulation showed complete release in 20 min as compared with the plain drug, which showed a limited dissolution rate.
format Articulo
Articulo
author Rao, Monica
Munjapara, Ghanshyam S.
Khole, Ishwar A.
author_facet Rao, Monica
Munjapara, Ghanshyam S.
Khole, Ishwar A.
author_sort Rao, Monica
title Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
title_short Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
title_full Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
title_fullStr Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
title_full_unstemmed Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
title_sort preparation and evaluation of self-microemulsifying drug delivery system of carvedilol
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8225
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_1.pdf
work_keys_str_mv AT raomonica preparationandevaluationofselfmicroemulsifyingdrugdeliverysystemofcarvedilol
AT munjaparaghanshyams preparationandevaluationofselfmicroemulsifyingdrugdeliverysystemofcarvedilol
AT kholeishwara preparationandevaluationofselfmicroemulsifyingdrugdeliverysystemofcarvedilol
bdutipo_str Repositorios
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