Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique

Repaglinide is a potent second generation oral hypoglycaemic agent widely used in treatment of non insulin dependent diabetic mellitus. The objective of the present study was to develop sustained release microspheres of repaglinide using ethyl cellulose and PEG 6000 as a matrix forming polymer. Mic...

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Autores principales:	Kshirsagar, Sanjay J., Patel, Smit J., Madgulkar, Ashwini R., Bhalekar, Mangesh R.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Microesferas ethyl cellulose; microsphere; PEG 6000; sustained release; spray drying Sistemas de Liberación de Medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8218 http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8218
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Microesferas ethyl cellulose; microsphere; PEG 6000; sustained release; spray drying Sistemas de Liberación de Medicamentos
spellingShingle	Farmacia Microesferas ethyl cellulose; microsphere; PEG 6000; sustained release; spray drying Sistemas de Liberación de Medicamentos Kshirsagar, Sanjay J. Patel, Smit J. Madgulkar, Ashwini R. Bhalekar, Mangesh R. Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
topic_facet	Farmacia Microesferas ethyl cellulose; microsphere; PEG 6000; sustained release; spray drying Sistemas de Liberación de Medicamentos
description	Repaglinide is a potent second generation oral hypoglycaemic agent widely used in treatment of non insulin dependent diabetic mellitus. The objective of the present study was to develop sustained release microspheres of repaglinide using ethyl cellulose and PEG 6000 as a matrix forming polymer. Microspheres were prepared by taking various concentrations of ethyl cellulose and PEG 6000 by spray drying technique. Prepared microspheres were evaluated for process yield, drug entrapment, particle size, SEM, FTIR, DSC and in vitro drug release. Process yield and drug entrapment was 40-45 % and 90-95 %, respectively. Particle size ranged in 5-22 µm and SEM study showed spherical shape and rough surface of microspheres. FTIR study and DSC analysis revealed the stable nature and amorphous dispersion of drug in the polymer matrix. In vitro release studies indicate retardation of release upto 12 h which can control both fasting blood glucose level and postprandial blood glucose.
format	Articulo Comunicacion
author	Kshirsagar, Sanjay J. Patel, Smit J. Madgulkar, Ashwini R. Bhalekar, Mangesh R.
author_facet	Kshirsagar, Sanjay J. Patel, Smit J. Madgulkar, Ashwini R. Bhalekar, Mangesh R.
author_sort	Kshirsagar, Sanjay J.
title	Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
title_short	Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
title_full	Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
title_fullStr	Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
title_full_unstemmed	Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
title_sort	formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8218 http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_5.pdf
work_keys_str_mv	AT kshirsagarsanjayj formulationandinvitroevaluationofrepaglinidemicrospherespreparedbyspraydryingtechnique AT patelsmitj formulationandinvitroevaluationofrepaglinidemicrospherespreparedbyspraydryingtechnique AT madgulkarashwinir formulationandinvitroevaluationofrepaglinidemicrospherespreparedbyspraydryingtechnique AT bhalekarmangeshr formulationandinvitroevaluationofrepaglinidemicrospherespreparedbyspraydryingtechnique
bdutipo_str	Repositorios
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Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique

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