Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former

The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although this class of polymers has been commonly used for direct compression, with the inte...

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Detalles Bibliográficos
Autores principales: Villanova, Janaina C.O., Consiglieri, Vladi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
controlled-release; matrices; dissolution kinetics; hydroxypropylmethyl cellulose; propranolol hydrochloride
Polímeros
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8207
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8207
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
controlled-release; matrices; dissolution kinetics; hydroxypropylmethyl cellulose; propranolol hydrochloride
Polímeros
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
controlled-release; matrices; dissolution kinetics; hydroxypropylmethyl cellulose; propranolol hydrochloride
Polímeros
Sistemas de Liberación de Medicamentos
Villanova, Janaina C.O.
Consiglieri, Vladi
Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
topic_facet Farmacia
controlled-release; matrices; dissolution kinetics; hydroxypropylmethyl cellulose; propranolol hydrochloride
Polímeros
Sistemas de Liberación de Medicamentos
description The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although this class of polymers has been commonly used for direct compression, with the intent of use reduced polymer concentrations to achieve controlled drug release, in this study tablets were produced by the wet granulation process. HPMC percentages ranged from 15-34 % and both soluble and non soluble diluents were tested in the 10 proposed tablet compositions. Dissolution testing of matrices was performed over a 12 h period in 1.2 pH medium (the first 2 h) and in pH 6.8 (10 h). Dissolution kinetic analysis was performed by applying Zero-order, First-order and Higuchi models with the aim of elucidating the drug release mechanism. All physical-chemical characteristics such as average weight, friability, hardness, diameter, height, and drug content were in accordance to the pharmacopeial specifications. Taking into account that PHCl is a very soluble drug, low concentrations (15 %) of HPMC were sufficient to reduce the drug release and to promote controlled release of PHCl, presenting good dissolution efficiencies, between 50 % and 63 %. The Higuchi model has presented the best fit to the 15 % HPMC formulations, indicating that the main release mechanism was diffusion. It could be concluded that the application of the wet granulation method reduced matrices erosion and promoted controlled release of the drug at low HPMC percentages.
format Articulo
Articulo
author Villanova, Janaina C.O.
Consiglieri, Vladi
author_facet Villanova, Janaina C.O.
Consiglieri, Vladi
author_sort Villanova, Janaina C.O.
title Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
title_short Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
title_full Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
title_fullStr Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
title_full_unstemmed Development and in vitro evaluation of propranolol hydrochloride controlled release tablets using HPMC as matrix former
title_sort development and in vitro evaluation of propranolol hydrochloride controlled release tablets using hpmc as matrix former
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8207
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_15.pdf
work_keys_str_mv AT villanovajanainaco developmentandinvitroevaluationofpropranololhydrochloridecontrolledreleasetabletsusinghpmcasmatrixformer
AT consiglierivladi developmentandinvitroevaluationofpropranololhydrochloridecontrolledreleasetabletsusinghpmcasmatrixformer
bdutipo_str Repositorios
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