Development and evaluation of modified locust bean microparticles for controlled drug delivery

The objective of the present study was to minimize the unwanted toxic effects of antihypertensive drug diltiazem hydrochloride (DTZ) by kinetic control of drug release from microparticles using chemically modified locust bean gum (MLGB) as carrier by emulsification method. DTZ was entrapped into gas...

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Detalles Bibliográficos
Autores principales: Gowda, D. Vishakant, Gupta, N. Vishal, Khan, Mohammed S., Singh, Mangla N.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
microparticles; diltiazem hydrochloride; modified locust bean gum; release kinetics
Sistemas de Liberación de Medicamentos
Agentes Antihipertensivos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8172
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8172
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
microparticles; diltiazem hydrochloride; modified locust bean gum; release kinetics
Sistemas de Liberación de Medicamentos
Agentes Antihipertensivos
spellingShingle Farmacia
microparticles; diltiazem hydrochloride; modified locust bean gum; release kinetics
Sistemas de Liberación de Medicamentos
Agentes Antihipertensivos
Gowda, D. Vishakant
Gupta, N. Vishal
Khan, Mohammed S.
Singh, Mangla N.
Development and evaluation of modified locust bean microparticles for controlled drug delivery
topic_facet Farmacia
microparticles; diltiazem hydrochloride; modified locust bean gum; release kinetics
Sistemas de Liberación de Medicamentos
Agentes Antihipertensivos
description The objective of the present study was to minimize the unwanted toxic effects of antihypertensive drug diltiazem hydrochloride (DTZ) by kinetic control of drug release from microparticles using chemically modified locust bean gum (MLGB) as carrier by emulsification method. DTZ was entrapped into gastro resistant, biodegradable locust bean gum microparticles using emulsification method. Solid, discrete, reproducible free flowing microparticles were obtained. The yield of the microparticles was up to 95 %. More than 97 % of the isolated microparticles were of particle size range of 325 to 455 µm. The obtained angle of repose, % Carr index and tapped density values were well within the limits, indicating that prepared microparticles had smooth surface, free flowing and good packing properties. Scanning Electron Microscopy photographs and calculated sphericity factor confirms that the prepared formulations are spherical in nature. Prepared microparticles were stable and compatible, as confirmed by DSC and FT-IR studies. It was observed that there is no significant release of the drug at gastric pH. The drug release was controlled more than 12 h. Intestinal drug release from microparticles was studied and compared with the release behavior of commercially available oral formulation Cardizam® CD. The release kinetics followed different transport mechanisms.
format Articulo
Articulo
author Gowda, D. Vishakant
Gupta, N. Vishal
Khan, Mohammed S.
Singh, Mangla N.
author_facet Gowda, D. Vishakant
Gupta, N. Vishal
Khan, Mohammed S.
Singh, Mangla N.
author_sort Gowda, D. Vishakant
title Development and evaluation of modified locust bean microparticles for controlled drug delivery
title_short Development and evaluation of modified locust bean microparticles for controlled drug delivery
title_full Development and evaluation of modified locust bean microparticles for controlled drug delivery
title_fullStr Development and evaluation of modified locust bean microparticles for controlled drug delivery
title_full_unstemmed Development and evaluation of modified locust bean microparticles for controlled drug delivery
title_sort development and evaluation of modified locust bean microparticles for controlled drug delivery
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8172
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_16.pdf
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AT guptanvishal developmentandevaluationofmodifiedlocustbeanmicroparticlesforcontrolleddrugdelivery
AT khanmohammeds developmentandevaluationofmodifiedlocustbeanmicroparticlesforcontrolleddrugdelivery
AT singhmanglan developmentandevaluationofmodifiedlocustbeanmicroparticlesforcontrolleddrugdelivery
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