Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity

The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal...

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Autores principales: Moinuddin, Ghulam, Devi, Kshama, Satish, Hanumantharayashetty, Khajuria, Deepak Kumar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antidepressant activity; imipramine; ocimum sanctum
Extractos Vegetales
Depresión
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8159
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8159
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antidepressant activity; imipramine; ocimum sanctum
Extractos Vegetales
Depresión
spellingShingle Farmacia
antidepressant activity; imipramine; ocimum sanctum
Extractos Vegetales
Depresión
Moinuddin, Ghulam
Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
topic_facet Farmacia
antidepressant activity; imipramine; ocimum sanctum
Extractos Vegetales
Depresión
description The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single administration of OS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However there was no significant potentiation of PST. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression.
format Articulo
Articulo
author Moinuddin, Ghulam
Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
author_facet Moinuddin, Ghulam
Devi, Kshama
Satish, Hanumantharayashetty
Khajuria, Deepak Kumar
author_sort Moinuddin, Ghulam
title Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
title_short Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
title_full Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
title_fullStr Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
title_full_unstemmed Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
title_sort comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8159
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_3.pdf
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