Evaluation of hypoglycemic potential and pre-clinical toxicology of Morus nigra L. (Moraceae)
The hypoglycemic potential of crude ethanolic extract of leaves (CEE-Mn) of the Morus nigra L. (Moraceae) was evaluated in normoglycemic rats. CEE-Mn (200 and 400 mg/kg) and metformin (500 mg/kg) were tested on the glucose tolerance oral test. The acute toxicity of CEE-Mn was performed 2.0 g/kg i...
Guardado en:
| Autores principales: | , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8106 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_14.pdf |
| Aporte de: |
| id |
I19-R120-10915-8106 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Extractos de plantas acute toxicity; hipoglycemic activity; Moraceae; Morus nigra L. Hipoglucemia Toxicidad Aguda |
| spellingShingle |
Farmacia Extractos de plantas acute toxicity; hipoglycemic activity; Moraceae; Morus nigra L. Hipoglucemia Toxicidad Aguda Quintans Júnior, Lucindo José Sá, Pedro G. S. de Oliveira, Roniere A. de Neves, Leonardo F. Silva, Fabrício S. Araújo, Edigênia C. da C. Oliveira, Ana P. de Guimarães, Amanda L. Silva Almeida, Jackson R. G. da Evaluation of hypoglycemic potential and pre-clinical toxicology of Morus nigra L. (Moraceae) |
| topic_facet |
Farmacia Extractos de plantas acute toxicity; hipoglycemic activity; Moraceae; Morus nigra L. Hipoglucemia Toxicidad Aguda |
| description |
The hypoglycemic potential of crude ethanolic extract of leaves (CEE-Mn) of the Morus nigra
L. (Moraceae) was evaluated in normoglycemic rats. CEE-Mn (200 and 400 mg/kg) and metformin (500
mg/kg) were tested on the glucose tolerance oral test. The acute toxicity of CEE-Mn was performed 2.0
g/kg intraperitoneally and 5.0 g/kg orally in Swiss mice. Blood was removed after seven days for laboratory
analysis of hematological and biochemical parameters. In the glucose tolerance oral test, only metformin
was able to reduce the glucose-induced hyperglycemia. Regarding acute toxicity no mortality and
no toxicity signs were observed, indicating low toxicity of the extract. In the evaluation of hematological
and biochemical parameters no alteration was observed. In conclusion, the CEE-Mn can be considered of
low toxicity but did not produce the expected hypoglycemic effect in the model used. |
| format |
Articulo Articulo |
| author |
Quintans Júnior, Lucindo José Sá, Pedro G. S. de Oliveira, Roniere A. de Neves, Leonardo F. Silva, Fabrício S. Araújo, Edigênia C. da C. Oliveira, Ana P. de Guimarães, Amanda L. Silva Almeida, Jackson R. G. da |
| author_facet |
Quintans Júnior, Lucindo José Sá, Pedro G. S. de Oliveira, Roniere A. de Neves, Leonardo F. Silva, Fabrício S. Araújo, Edigênia C. da C. Oliveira, Ana P. de Guimarães, Amanda L. Silva Almeida, Jackson R. G. da |
| author_sort |
Quintans Júnior, Lucindo José |
| title |
Evaluation of hypoglycemic potential and
pre-clinical toxicology of Morus nigra L. (Moraceae) |
| title_short |
Evaluation of hypoglycemic potential and
pre-clinical toxicology of Morus nigra L. (Moraceae) |
| title_full |
Evaluation of hypoglycemic potential and
pre-clinical toxicology of Morus nigra L. (Moraceae) |
| title_fullStr |
Evaluation of hypoglycemic potential and
pre-clinical toxicology of Morus nigra L. (Moraceae) |
| title_full_unstemmed |
Evaluation of hypoglycemic potential and
pre-clinical toxicology of Morus nigra L. (Moraceae) |
| title_sort |
evaluation of hypoglycemic potential and
pre-clinical toxicology of morus nigra l. (moraceae) |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8106 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_14.pdf |
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Repositorios |
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