Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30

Solid dispersions (SDs) of poorly water soluble diacerein were prepared with polyvinylpyrrolidone K30 at drug to polymer ratios of 1:1, 1:3 and 1:5 w/w utilizing kneading technique. Physical mixture (PM) was prepared at drug to polymer ratio of 1:5 w/w for comparison. All formulations were further c...

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Autores principales: Patil, Snehal B., Shete, Tushar K., Narade, Sarika B., Surve, Sharda S., Khan, Ziya K., Bhokare, Kuldeep K., Pore, Yogesh V.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
caracterización; diacereína; disolución; povidona K30; dispersión sólida
characterization; diacerein,; dissolution; polyvinylpyrrolidone K30; solid dispersion
caracterização; diacereína; dissolução; polivinilpirrolidona K30; dispersão dos sólidos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8100
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8100
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
caracterización; diacereína; disolución; povidona K30; dispersión sólida
characterization; diacerein,; dissolution; polyvinylpyrrolidone K30; solid dispersion
caracterização; diacereína; dissolução; polivinilpirrolidona K30; dispersão dos sólidos
spellingShingle Farmacia
caracterización; diacereína; disolución; povidona K30; dispersión sólida
characterization; diacerein,; dissolution; polyvinylpyrrolidone K30; solid dispersion
caracterização; diacereína; dissolução; polivinilpirrolidona K30; dispersão dos sólidos
Patil, Snehal B.
Shete, Tushar K.
Narade, Sarika B.
Surve, Sharda S.
Khan, Ziya K.
Bhokare, Kuldeep K.
Pore, Yogesh V.
Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
topic_facet Farmacia
caracterización; diacereína; disolución; povidona K30; dispersión sólida
characterization; diacerein,; dissolution; polyvinylpyrrolidone K30; solid dispersion
caracterização; diacereína; dissolução; polivinilpirrolidona K30; dispersão dos sólidos
description Solid dispersions (SDs) of poorly water soluble diacerein were prepared with polyvinylpyrrolidone K30 at drug to polymer ratios of 1:1, 1:3 and 1:5 w/w utilizing kneading technique. Physical mixture (PM) was prepared at drug to polymer ratio of 1:5 w/w for comparison. All formulations were further characterized by TLC, DSC, XRPD, SEM and dissolution studies. TLC indicated an absence of chemical interaction between drug and polymer. A prominent decrease in the crystallinity was accounted for diacerein in binary systems from XRPD data. DSC thermograms revealed a uniform molecular dispersion and generation of amorphous entities of drug accompanied by loss of crystalline and irregular shape with distinct changes in surface morphological features of diacerein detected in SEM photomicrographs. The drug dissolution properties of SDs were significantly improved (DP2: 95.87-100%) in comparison to crystalline diacerein and PM suggesting suitability of kneading method for improving the release rate properties of diacerein.
format Articulo
Articulo
author Patil, Snehal B.
Shete, Tushar K.
Narade, Sarika B.
Surve, Sharda S.
Khan, Ziya K.
Bhokare, Kuldeep K.
Pore, Yogesh V.
author_facet Patil, Snehal B.
Shete, Tushar K.
Narade, Sarika B.
Surve, Sharda S.
Khan, Ziya K.
Bhokare, Kuldeep K.
Pore, Yogesh V.
author_sort Patil, Snehal B.
title Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
title_short Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
title_full Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
title_fullStr Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
title_full_unstemmed Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30
title_sort physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with pvp k30
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8100
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_9.pdf
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