Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design
The present investigation deals with the development of floating matrix tablet containing Ofloxacin, to prolong the gastric residence time, thereby effective in eradication of Helicobacter pylori from the gastric mucosa. A 3<sup>2</sup> factorial design was employed to formulate floating...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8099 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-8099 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Medicamentos Helicobacter pylori ofloxacin; floating matrix; citric acid; HPMC; SCMC; factorial design antibiótico |
| spellingShingle |
Farmacia Medicamentos Helicobacter pylori ofloxacin; floating matrix; citric acid; HPMC; SCMC; factorial design antibiótico Bera, Hriday Mandal, Bivash Sinha, Chandrima Dey, Sanjoy K. Bera, Rammohan Ghosh, Lakshmi K. Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| topic_facet |
Farmacia Medicamentos Helicobacter pylori ofloxacin; floating matrix; citric acid; HPMC; SCMC; factorial design antibiótico |
| description |
The present investigation deals with the development of floating matrix tablet containing Ofloxacin, to prolong the gastric residence time, thereby effective in eradication of Helicobacter pylori from the gastric mucosa. A 3<sup>2</sup> factorial design was employed to formulate floating matrix tablet selecting polymer blend ratio [hydroxypropyl methylcellulose (HPMC) / sodium carboxymethylcellulose (SCMC)] and content of citric acid as independent variables. Time required for 50 % of drug release (t<sub>50</sub> %), percentage drug release at 8 h (Q<sub>8</sub>), floating duration (h) and diffusion exponent (n) were selected as dependent variables. Multiple regression analysis with two way ANOVA revealed statistically significant effect of the two independent variables on the responses studied (P < 0.01). Floating duration varied from 7.5 h to 20 h, Q<sub>8</sub> varied from ~ 76 % to ~100 % whereas t<sub>50</sub> % ranged from 1.7 h to 3.7 h. The kinetics of drug release fitted best to Higuchi diffusion controlled model. |
| format |
Articulo Articulo |
| author |
Bera, Hriday Mandal, Bivash Sinha, Chandrima Dey, Sanjoy K. Bera, Rammohan Ghosh, Lakshmi K. |
| author_facet |
Bera, Hriday Mandal, Bivash Sinha, Chandrima Dey, Sanjoy K. Bera, Rammohan Ghosh, Lakshmi K. |
| author_sort |
Bera, Hriday |
| title |
Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| title_short |
Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| title_full |
Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| title_fullStr |
Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| title_full_unstemmed |
Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| title_sort |
effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8099 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_7.pdf |
| work_keys_str_mv |
AT berahriday effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign AT mandalbivash effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign AT sinhachandrima effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign AT deysanjoyk effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign AT berarammohan effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign AT ghoshlakshmik effectofcitricacidandpolymerblendoncharacteristicsofofloxacinfloatingmatrixtabletsbyfactorialdesign |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487987265537 |