Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice

D-002 (beeswax alcohols) contains triacontanol as most abundant component. Local application of triacontanol has been shown anti-inflammatory effects on chemically-induced dermatitis and oral treatment with D-002 produced anti-inflammatory effects in carrageenan-induced pleurisy and cotton granuloma...

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Autores principales: Ravelo, Yazmin, Molina, Vivian, Carbajal, Daisy, Arruzazabala, María de Lourdes, Más, Rosa, Oyarzábal, Ambar, Pérez, Yohani, Jiménez, Sonia
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
beeswax alcohols; D-002; edema; inflammation; myeloperoxidase; xylene
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8088
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8088
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
beeswax alcohols; D-002; edema; inflammation; myeloperoxidase; xylene
spellingShingle Farmacia
beeswax alcohols; D-002; edema; inflammation; myeloperoxidase; xylene
Ravelo, Yazmin
Molina, Vivian
Carbajal, Daisy
Arruzazabala, María de Lourdes
Más, Rosa
Oyarzábal, Ambar
Pérez, Yohani
Jiménez, Sonia
Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
topic_facet Farmacia
beeswax alcohols; D-002; edema; inflammation; myeloperoxidase; xylene
description D-002 (beeswax alcohols) contains triacontanol as most abundant component. Local application of triacontanol has been shown anti-inflammatory effects on chemically-induced dermatitis and oral treatment with D-002 produced anti-inflammatory effects in carrageenan-induced pleurisy and cotton granuloma in rats, but its effects on xylene-induced mouse ear edema had not been studied. This study investigated the effects of single oral and topical doses of D-002 on this model. Oral dosing groups were composed by one negative control and six xylene-treated, one positive control, four D-002-treated (25, 50, 200, 400 mg/kg), and one indomethacin-treated (10 mg/kg). Topical dosing groups were conformed by one negative control and four xylene- treated, one positive control and three D-002-treated (2.5, 5, 10 %). Single oral doses of D-002 significantly and dose-dependently reduced edema formation and myeloperoxidase activity, but single topical applications unchanged both variables. Concluding, acute oral treatment with D- 002 was effective to decrease xylene-induced mouse ear edema, but single topical doses were ineffective.
format Articulo
Comunicacion
author Ravelo, Yazmin
Molina, Vivian
Carbajal, Daisy
Arruzazabala, María de Lourdes
Más, Rosa
Oyarzábal, Ambar
Pérez, Yohani
Jiménez, Sonia
author_facet Ravelo, Yazmin
Molina, Vivian
Carbajal, Daisy
Arruzazabala, María de Lourdes
Más, Rosa
Oyarzábal, Ambar
Pérez, Yohani
Jiménez, Sonia
author_sort Ravelo, Yazmin
title Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
title_short Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
title_full Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
title_fullStr Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
title_full_unstemmed Effects of single oral and topical administration of D-002 (beeswax alcohols) on xylene-induced ear edema in mice
title_sort effects of single oral and topical administration of d-002 (beeswax alcohols) on xylene-induced ear edema in mice
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8088
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_2_5.pdf
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