Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use

The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageen...

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Autores principales: Bermúdez, José M., Grau, Ricardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
injectable depot; modified release; thermosensitive gel
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8076
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8076
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
injectable depot; modified release; thermosensitive gel
spellingShingle Farmacia
injectable depot; modified release; thermosensitive gel
Bermúdez, José M.
Grau, Ricardo
Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
topic_facet Farmacia
injectable depot; modified release; thermosensitive gel
description The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageenan reinforces the structure of poloxamer gels (after 50 h of testing only 20 % of the system is eroding) and allows to modulate the release rate of progesterone as a function of formulations composition. The elastic modulus of sole poloxamer gels (G' = 56 Pa) increases significantly in presence of carrageenan (G' = 1 347 Pa) at 10 °C. The gelation temperature of tested formulations is between 17 and 22 °C and the gelation process is very quick. Poloxamer-carrageenan systems offer a promissory alternative approach to development of injectable depot systems for veterinary use.ies).
format Articulo
Articulo
author Bermúdez, José M.
Grau, Ricardo
author_facet Bermúdez, José M.
Grau, Ricardo
author_sort Bermúdez, José M.
title Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
title_short Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
title_full Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
title_fullStr Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
title_full_unstemmed Injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
title_sort injectable thermosensitive gels based in poloxamer as modified drug release systems for veterinary use
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8076
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_16.pdf
work_keys_str_mv AT bermudezjosem injectablethermosensitivegelsbasedinpoloxamerasmodifieddrugreleasesystemsforveterinaryuse
AT grauricardo injectablethermosensitivegelsbasedinpoloxamerasmodifieddrugreleasesystemsforveterinaryuse
bdutipo_str Repositorios
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