Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation

Biodegradable microspheres of Tramadol Hydrochloride (TmH) were developed using simple phase separation technique. Poly lactide-co-glycolide (PLGA) was employed as a release controlling polymer. Simple phase separation method was adopted to prepare microspheres; Dichloromethane (DCM) and Liquid P...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Aamir, Muhammad N., Ahmad, Mahmood, Murtaza, Ghulam, Akhtar, Naveed, Khan, Shujaat A., Usman, Muhammad
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
biodegradable microspheres; in vitro evaluation; non-solvent addition; PLGA
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8042
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8042
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
biodegradable microspheres; in vitro evaluation; non-solvent addition; PLGA
spellingShingle Farmacia
biodegradable microspheres; in vitro evaluation; non-solvent addition; PLGA
Aamir, Muhammad N.
Ahmad, Mahmood
Murtaza, Ghulam
Akhtar, Naveed
Khan, Shujaat A.
Usman, Muhammad
Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
topic_facet Farmacia
biodegradable microspheres; in vitro evaluation; non-solvent addition; PLGA
description Biodegradable microspheres of Tramadol Hydrochloride (TmH) were developed using simple phase separation technique. Poly lactide-co-glycolide (PLGA) was employed as a release controlling polymer. Simple phase separation method was adopted to prepare microspheres; Dichloromethane (DCM) and Liquid Paraffin (LP) were employed as solvent and non-solvent respectively. Five kinetic models were applied to assess and describe the mechanism and pattern of TmH release from biodegradable microspheres. Biodegradable microspheres were subjected to FTIR, DSC and XRD, to evaluate TmH-PLGA interaction. Retardation in the release of TmH was observed as PLGA concentration was increased. Kinetics of drug release was following higuchi model. The microspheres exhibited no interaction between TmH and PLGA. Biodegradable microspheres of TmH can be produced using phase separation method. Microspheres were stable with no drug-polymer interaction. The accelerated stability studies also ensured the physicochemical integrity as differences of release profile over the period of three months were insignificant.
format Articulo
Articulo
author Aamir, Muhammad N.
Ahmad, Mahmood
Murtaza, Ghulam
Akhtar, Naveed
Khan, Shujaat A.
Usman, Muhammad
author_facet Aamir, Muhammad N.
Ahmad, Mahmood
Murtaza, Ghulam
Akhtar, Naveed
Khan, Shujaat A.
Usman, Muhammad
author_sort Aamir, Muhammad N.
title Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
title_short Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
title_full Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
title_fullStr Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
title_full_unstemmed Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
title_sort synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8042
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_15.pdf
work_keys_str_mv AT aamirmuhammadn synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
AT ahmadmahmood synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
AT murtazaghulam synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
AT akhtarnaveed synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
AT khanshujaata synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
AT usmanmuhammad synthesisofbiodegradablemicrospheresoftramadolbysimplephaseseparationtechniqueandtheirinvitroevaluation
bdutipo_str Repositorios
_version_ 1764820486939738115

Ejemplares similares