Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium

The aim of this study was to develop topical hydrogels containing diclofenac potassium (DP) at 1 % w/v concentration using conventional hydrophilic hydroxypropyl methyl cellulose (HPMC, 50cPs) and modified hydrophobic hydroxypropyl methyl cellulose (HPMC, 90L grade). The differences between in vi...

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Autores principales: Ghosal, Kajal, Rajabalaya, Rajan, Chakraborty, Subrata, Nanda, Arunabha
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
diclofenac potassium; hydrophobic; hydrophilic; release kinetics; release models
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8040
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8040
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
diclofenac potassium; hydrophobic; hydrophilic; release kinetics; release models
spellingShingle Farmacia
diclofenac potassium; hydrophobic; hydrophilic; release kinetics; release models
Ghosal, Kajal
Rajabalaya, Rajan
Chakraborty, Subrata
Nanda, Arunabha
Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
topic_facet Farmacia
diclofenac potassium; hydrophobic; hydrophilic; release kinetics; release models
description The aim of this study was to develop topical hydrogels containing diclofenac potassium (DP) at 1 % w/v concentration using conventional hydrophilic hydroxypropyl methyl cellulose (HPMC, 50cPs) and modified hydrophobic hydroxypropyl methyl cellulose (HPMC, 90L grade). The differences between in vitro release profiles of both types of polymer based hydrogels were studied using model dependent equations. Three formulations were prepared from hydrophobic HPMC at 1 %, 1.5 % and 2 % (w/v) concentration. Other two formulations were prepared from hydrophilic HPMC at 12 % and 15 % (w/v) concentration. Hydrophobic formulations of higher viscosity with small quantity of polymer show higher release compared to hydrophilic formulations of lower viscosity with higher polymer concentration. Combined effect of swelling and erosion leads to anomalous diffusion in case of hydrophobic HPMC based hydrogels whereas only swelling leads to Fickian diffusion in case of hydrophilic HPMC based hydrogels. The formulations follow Higuchi release pattern as well as Weibull model.
format Articulo
Articulo
author Ghosal, Kajal
Rajabalaya, Rajan
Chakraborty, Subrata
Nanda, Arunabha
author_facet Ghosal, Kajal
Rajabalaya, Rajan
Chakraborty, Subrata
Nanda, Arunabha
author_sort Ghosal, Kajal
title Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
title_short Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
title_full Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
title_fullStr Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
title_full_unstemmed Formulation and characterization of both hydrophilic and hydrophobic HPMC based hydrogels containing diclofenac potassium
title_sort formulation and characterization of both hydrophilic and hydrophobic hpmc based hydrogels containing diclofenac potassium
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8040
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_13.pdf
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bdutipo_str Repositorios
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