In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers

The main objective of the present study is to improve the permeation of acyclovir sodium (ACV) across stratum corneum (SC) from HPMC gel formulations. We have also investigated the role of chemical permeation enhancers like dimethyl sulfoxide, ethanol, limonene and sodium taurodeoxycholate on the tr...

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Autores principales: Mateti, Ashok, Jukanti, Raju, Bandari, Suresh, Veerareddy, Prabhakar Reddy
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
acyclovir sodium
flux
gels
hydroxypropylmethylcellulose
permeation enhancers
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7997
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7997
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
acyclovir sodium
flux
gels
hydroxypropylmethylcellulose
permeation enhancers
spellingShingle Farmacia
acyclovir sodium
flux
gels
hydroxypropylmethylcellulose
permeation enhancers
Mateti, Ashok
Jukanti, Raju
Bandari, Suresh
Veerareddy, Prabhakar Reddy
In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
topic_facet Farmacia
acyclovir sodium
flux
gels
hydroxypropylmethylcellulose
permeation enhancers
description The main objective of the present study is to improve the permeation of acyclovir sodium (ACV) across stratum corneum (SC) from HPMC gel formulations. We have also investigated the role of chemical permeation enhancers like dimethyl sulfoxide, ethanol, limonene and sodium taurodeoxycholate on the transcutaneous permeation of ACV from HPMC gels. The optimized formulations were characterized and subjected to in vitro permeation study using excised rat abdominal skin. The histological examination of the skin was studied to understand the mechanisms involved in the permeation of ACV across skin. The cumulative amount of ACV permeated and the increase in permeation parameters (Jss, Kp and ER) were significantly higher for gel formulations compared to marketed formulation. A 2 to 4 fold increase in enhancement ratio clearly indicates the potential of formulating ACV into a gel.
format Articulo
Comunicacion
author Mateti, Ashok
Jukanti, Raju
Bandari, Suresh
Veerareddy, Prabhakar Reddy
author_facet Mateti, Ashok
Jukanti, Raju
Bandari, Suresh
Veerareddy, Prabhakar Reddy
author_sort Mateti, Ashok
title In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
title_short In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
title_full In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
title_fullStr In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
title_full_unstemmed In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers
title_sort in vitro transcutaneous permeation of acyclovir sodium from hpmc gels: role of chemical permeation enhancers
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7997
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_2.pdf
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