Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics

Transdermal drug delivery systems of venlafaxine hydrochloride were prepared by using combination of hydrophilic (HPMC E15) and hydrophobic (ERS100 and ERL 100) polymers in 1:5, 2:4, 3:3, 4:2, 5:1 ratios by solvent casting technique with 15 % v/w propylene glycol as plasticizer. The drug permeation...

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Detalles Bibliográficos
Autores principales:	Rajula, Karunakar, Bandari, Suresh, Jukanti, Raju, Veerareddy, Prabhakar Reddy
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Medicamentos venlafaxine hydrochloride; transdermal drug delivery; eudragits; HPMC; permeability Farmacología Permeabilidad
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7980 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_19.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7980
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Medicamentos venlafaxine hydrochloride; transdermal drug delivery; eudragits; HPMC; permeability Farmacología Permeabilidad
spellingShingle	Farmacia Medicamentos venlafaxine hydrochloride; transdermal drug delivery; eudragits; HPMC; permeability Farmacología Permeabilidad Rajula, Karunakar Bandari, Suresh Jukanti, Raju Veerareddy, Prabhakar Reddy Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
topic_facet	Farmacia Medicamentos venlafaxine hydrochloride; transdermal drug delivery; eudragits; HPMC; permeability Farmacología Permeabilidad
description	Transdermal drug delivery systems of venlafaxine hydrochloride were prepared by using combination of hydrophilic (HPMC E15) and hydrophobic (ERS100 and ERL 100) polymers in 1:5, 2:4, 3:3, 4:2, 5:1 ratios by solvent casting technique with 15 % v/w propylene glycol as plasticizer. The drug permeation studies revealed that drug permeation increased proportionally with increasing HPMC ratio where ERS 100 as hydrophobic polymer but in case of ERL 100 as hydrophobic polymer proportional increase was not obtained this may be due to increased diffusion path length. The drug permeation kinetics followed zero order profile with diffusion mechanism. The average steady state flux obtained with HPMC: ERL 100 (3:3) was 193.2 μg/cm<sup>2</sup> /h and the same was increased to 257 μg/cm<sup>2</sup> /h with the incorporation of 5 % v/w of dimethyl sulfoxide as permeation enhancer that was 3 fold of target flux (86 μg/cm<sup>2</sup> /h). The FTIR studies showed drug-polymer compatibility.
format	Articulo Articulo
author	Rajula, Karunakar Bandari, Suresh Jukanti, Raju Veerareddy, Prabhakar Reddy
author_facet	Rajula, Karunakar Bandari, Suresh Jukanti, Raju Veerareddy, Prabhakar Reddy
author_sort	Rajula, Karunakar
title	Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
title_short	Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
title_full	Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
title_fullStr	Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
title_full_unstemmed	Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
title_sort	venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7980 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_19.pdf
work_keys_str_mv	AT rajulakarunakar venlafaxinehydrochloridetransdermalpatcheseffectofhydrophilicandhydrophobicmatrixoninvitrocharacteristics AT bandarisuresh venlafaxinehydrochloridetransdermalpatcheseffectofhydrophilicandhydrophobicmatrixoninvitrocharacteristics AT jukantiraju venlafaxinehydrochloridetransdermalpatcheseffectofhydrophilicandhydrophobicmatrixoninvitrocharacteristics AT veerareddyprabhakarreddy venlafaxinehydrochloridetransdermalpatcheseffectofhydrophilicandhydrophobicmatrixoninvitrocharacteristics
bdutipo_str	Repositorios
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Venlafaxine hydrochloride transdermal patches: effect of hydrophilic and hydrophobic matrix on in vitro characteristics

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