Dual coated microparticles for intestinal delivery of nimesulide
Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and increase patient compliance. The first coating was applied by chitosan using pH chan...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7975 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_14.pdf |
| Aporte de: |
| id |
I19-R120-10915-7975 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia chitosan; dual coating; ethyl cellulose; microencapsulation; microparticles; nimesulide Medicamentos Composición de medicamentos Farmacología |
| spellingShingle |
Farmacia chitosan; dual coating; ethyl cellulose; microencapsulation; microparticles; nimesulide Medicamentos Composición de medicamentos Farmacología Khan, Shujaat A. Ahmad, Mahmood Murtaza, Ghulam Aamir, Muhammad N. Akhtar, Naveed Dual coated microparticles for intestinal delivery of nimesulide |
| topic_facet |
Farmacia chitosan; dual coating; ethyl cellulose; microencapsulation; microparticles; nimesulide Medicamentos Composición de medicamentos Farmacología |
| description |
Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and increase patient compliance. The first coating was applied by chitosan using pH change method followed by second coating of ethyl cellulose using thermal change method. This process was analysed for its capability to produce microparticles of uniform size, good flowability, uniform drug loading and maximum entrapment efficacy and the absence of interaction between drug and process parameters as well as the polymers confirmed by XRD and FTIR analysis. In vitro release study was carried out in simulated gastric fluid (SGF) for first 2 h and simulated intestinal fluid (SIF) for next 6 h. The formulation M7 and M8 that contained chitosan and ethyl cellulose in the concentration of 1:1 and 1:2 (M1:EC) were found to achieve the targets of the present study such as uniform intestinal release of acidic drug and thus improves the patient compliance. |
| format |
Articulo Articulo |
| author |
Khan, Shujaat A. Ahmad, Mahmood Murtaza, Ghulam Aamir, Muhammad N. Akhtar, Naveed |
| author_facet |
Khan, Shujaat A. Ahmad, Mahmood Murtaza, Ghulam Aamir, Muhammad N. Akhtar, Naveed |
| author_sort |
Khan, Shujaat A. |
| title |
Dual coated microparticles for intestinal delivery of nimesulide |
| title_short |
Dual coated microparticles for intestinal delivery of nimesulide |
| title_full |
Dual coated microparticles for intestinal delivery of nimesulide |
| title_fullStr |
Dual coated microparticles for intestinal delivery of nimesulide |
| title_full_unstemmed |
Dual coated microparticles for intestinal delivery of nimesulide |
| title_sort |
dual coated microparticles for intestinal delivery of nimesulide |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7975 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_14.pdf |
| work_keys_str_mv |
AT khanshujaata dualcoatedmicroparticlesforintestinaldeliveryofnimesulide AT ahmadmahmood dualcoatedmicroparticlesforintestinaldeliveryofnimesulide AT murtazaghulam dualcoatedmicroparticlesforintestinaldeliveryofnimesulide AT aamirmuhammadn dualcoatedmicroparticlesforintestinaldeliveryofnimesulide AT akhtarnaveed dualcoatedmicroparticlesforintestinaldeliveryofnimesulide |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487129530368 |