The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals
The present study was undertaken to evaluate immunomodulatory activity of Crocus sativus and its active constituent crocin. Crocus sativus and crocin were administered orally at doses of 50 mg/kg and 9.69 mg/kg, respectively. The dose of crocin was selected based on the amount present in 50 mg of...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2010
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7972 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_11.pdf |
| Aporte de: |
| id |
I19-R120-10915-7972 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia cellular immunity; Crocus sativus; crocin; humoral immunity; immunomodulation Inmunidad celular Farmacología Plantas medicinales |
| spellingShingle |
Farmacia cellular immunity; Crocus sativus; crocin; humoral immunity; immunomodulation Inmunidad celular Farmacología Plantas medicinales Khajuria, Deepak Kumar Asad, Mohammed Asdaq, Syed M.B. Kumar, Prasanna The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| topic_facet |
Farmacia cellular immunity; Crocus sativus; crocin; humoral immunity; immunomodulation Inmunidad celular Farmacología Plantas medicinales |
| description |
The present study was undertaken to evaluate immunomodulatory activity of Crocus sativus
and its active constituent crocin. Crocus sativus and crocin were administered orally at doses of 50 mg/kg
and 9.69 mg/kg, respectively. The dose of crocin was selected based on the amount present in 50 mg of saffron.
The effect on cellular immunity was evaluated using the neutrophil adhesion test, cyclophosphamideinduced
neutropenia and carbon clearance assay, while the effect on humoral immunity was studied using
the mice lethality test, serum immunoglobulins estimation and the indirect haemagglutination assay. The
results revealed that Crocus sativus and crocin stimulate both cellular and humoral immune responses.
Both these agents produced a significant increase in adhesion of neutrophils, attenuation of cyclphosphamide-
induced neutropenia and an increase in phagocytic index in carbon clearance assay indicating
their effect on cellular immunity. The effect on humoral immune response was demonstrated by reduction
in mortality in the mice lethality assay, a rise in serum immunoglobulin levels and an increase in thymus
gland weight and haemagglutination titre value. |
| format |
Articulo Articulo |
| author |
Khajuria, Deepak Kumar Asad, Mohammed Asdaq, Syed M.B. Kumar, Prasanna |
| author_facet |
Khajuria, Deepak Kumar Asad, Mohammed Asdaq, Syed M.B. Kumar, Prasanna |
| author_sort |
Khajuria, Deepak Kumar |
| title |
The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| title_short |
The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| title_full |
The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| title_fullStr |
The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| title_full_unstemmed |
The potency of Crocus sativus (Saffron) and its constituent crocin as an immunomodulator in animals |
| title_sort |
potency of crocus sativus (saffron) and its constituent crocin as an immunomodulator in animals |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7972 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_11.pdf |
| work_keys_str_mv |
AT khajuriadeepakkumar thepotencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT asadmohammed thepotencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT asdaqsyedmb thepotencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT kumarprasanna thepotencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT khajuriadeepakkumar potencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT asadmohammed potencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT asdaqsyedmb potencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals AT kumarprasanna potencyofcrocussativussaffronanditsconstituentcrocinasanimmunomodulatorinanimals |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487093878785 |