Antiinflammatory activity of Cayaponia podantha crude extract and fractions

The effects of the crude extract and fractions of Cayaponia podantha (Cp) on experimental inflammation models were investigated. Paw edema induced by carrageenan (Cg) and peritonitis induced by Cg, LPS, and LTB4 were evaluated in rats treated orally with different doses of extract. Croton oil (CO) i...

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Autores principales:	Oliveira de Melo, Juliana, Arruda, Laura L. M., Truiti, Maria C.T., Caparroz-Assef, Silvana M., Cuman, Roberto K. N., Bersani Amado, Ciomar Aparecida
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Farmacología anti-inflammatory activity; Cayaponia podantha; ear edema; paw edema; peritonitis Extractos de plantas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7963 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_2.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7963
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología anti-inflammatory activity; Cayaponia podantha; ear edema; paw edema; peritonitis Extractos de plantas
spellingShingle	Farmacia Farmacología anti-inflammatory activity; Cayaponia podantha; ear edema; paw edema; peritonitis Extractos de plantas Oliveira de Melo, Juliana Arruda, Laura L. M. Truiti, Maria C.T. Caparroz-Assef, Silvana M. Cuman, Roberto K. N. Bersani Amado, Ciomar Aparecida Antiinflammatory activity of Cayaponia podantha crude extract and fractions
topic_facet	Farmacia Farmacología anti-inflammatory activity; Cayaponia podantha; ear edema; paw edema; peritonitis Extractos de plantas
description	The effects of the crude extract and fractions of Cayaponia podantha (Cp) on experimental inflammation models were investigated. Paw edema induced by carrageenan (Cg) and peritonitis induced by Cg, LPS, and LTB4 were evaluated in rats treated orally with different doses of extract. Croton oil (CO) induced ear edema and the determination of MPO activity were evaluated in mice. Crude Cp extract and hexane (HF), ethyl-acetate (AF) and hidromethanol (MF) fractions were topically applied immediately after the application of the CO. Four hours after Cg injection, animals treated with crude extract (250 and 500 mg/kg) displayed significantly decreased paw edema. The Cp extract (250, 500, and 750 mg/kg) decreased vascular permeability and leukocyte migration in the peritonitis model in the 3rd h after induction of the inflammatory reaction. Furthermore, the 500 mg/kg dose of Cp extract also reduced LPS- and LTB4-induced migration. Crude extract and hexane and ethyl-acetate fractions (5.0 mg) significantly inhibited ear edema and MPO activity. Our results showed that Cp crude extract and fractions exhibited anti-inflammatory effects when they are administered orally or topically in animals.
format	Articulo Articulo
author	Oliveira de Melo, Juliana Arruda, Laura L. M. Truiti, Maria C.T. Caparroz-Assef, Silvana M. Cuman, Roberto K. N. Bersani Amado, Ciomar Aparecida
author_facet	Oliveira de Melo, Juliana Arruda, Laura L. M. Truiti, Maria C.T. Caparroz-Assef, Silvana M. Cuman, Roberto K. N. Bersani Amado, Ciomar Aparecida
author_sort	Oliveira de Melo, Juliana
title	Antiinflammatory activity of Cayaponia podantha crude extract and fractions
title_short	Antiinflammatory activity of Cayaponia podantha crude extract and fractions
title_full	Antiinflammatory activity of Cayaponia podantha crude extract and fractions
title_fullStr	Antiinflammatory activity of Cayaponia podantha crude extract and fractions
title_full_unstemmed	Antiinflammatory activity of Cayaponia podantha crude extract and fractions
title_sort	antiinflammatory activity of cayaponia podantha crude extract and fractions
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7963 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_2.pdf
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bdutipo_str	Repositorios
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Antiinflammatory activity of Cayaponia podantha crude extract and fractions

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