Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin

Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lhez, Lucía, Allemandi, Daniel A., Palma, Santiago D., Pappano, Nora B., Debattista, Nora B.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia abdominal pig skin; enhancers; probenecid permeation; transdermal delivery system Farmacología Medicamentos Evaluación de medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7954 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_2_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7954
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia abdominal pig skin; enhancers; probenecid permeation; transdermal delivery system Farmacología Medicamentos Evaluación de medicamentos
spellingShingle	Farmacia abdominal pig skin; enhancers; probenecid permeation; transdermal delivery system Farmacología Medicamentos Evaluación de medicamentos Lhez, Lucía Allemandi, Daniel A. Palma, Santiago D. Pappano, Nora B. Debattista, Nora B. Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
topic_facet	Farmacia abdominal pig skin; enhancers; probenecid permeation; transdermal delivery system Farmacología Medicamentos Evaluación de medicamentos
description	Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comparatively to lipophilic vehicle (vaseline), carbopol dispersions seen to be more convenient as vehicle for topical administration of probenecid. The results obtained from this study may be helpful in the development of a probenecid transdermal drug delivery system.
format	Articulo Comunicacion
author	Lhez, Lucía Allemandi, Daniel A. Palma, Santiago D. Pappano, Nora B. Debattista, Nora B.
author_facet	Lhez, Lucía Allemandi, Daniel A. Palma, Santiago D. Pappano, Nora B. Debattista, Nora B.
author_sort	Lhez, Lucía
title	Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
title_short	Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
title_full	Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
title_fullStr	Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
title_full_unstemmed	Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
title_sort	transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7954 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_2_1.pdf
work_keys_str_mv	AT lhezlucia transdermaldeliveryofprobenecidtheeffectsofvehiclesandenhancersonpermeationthroughpigskin AT allemandidaniela transdermaldeliveryofprobenecidtheeffectsofvehiclesandenhancersonpermeationthroughpigskin AT palmasantiagod transdermaldeliveryofprobenecidtheeffectsofvehiclesandenhancersonpermeationthroughpigskin AT pappanonorab transdermaldeliveryofprobenecidtheeffectsofvehiclesandenhancersonpermeationthroughpigskin AT debattistanorab transdermaldeliveryofprobenecidtheeffectsofvehiclesandenhancersonpermeationthroughpigskin
bdutipo_str	Repositorios
_version_	1764820486871580676

Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin

Ejemplares similares