Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma
Paeonol is a micromolecular phenolic compound and it is the main component of Chinese herbal medicine that has been isolated from the root bark of Paeonia moutan. Paeonol is identified to have various physiological activities. In this study the antitumor activity and the possible mechanisms of pa...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7920 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-7920 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología breast cancer; Bcl-2; C-erbB-2; P53; paeonol Plantas medicinales Compuesto químico |
| spellingShingle |
Farmacia Farmacología breast cancer; Bcl-2; C-erbB-2; P53; paeonol Plantas medicinales Compuesto químico Tian, Yongzhi Wang, Jianjie Li, Qingwang Ou, Yetao Li, Chunjiang Sun, Xiaoxin Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| topic_facet |
Farmacia Farmacología breast cancer; Bcl-2; C-erbB-2; P53; paeonol Plantas medicinales Compuesto químico |
| description |
Paeonol is a micromolecular phenolic compound and it is the main component of Chinese
herbal medicine that has been isolated from the root bark of Paeonia moutan. Paeonol is identified to
have various physiological activities. In this study the antitumor activity and the possible mechanisms of
paeonol were investigated in mice bearing EMT6 breast cancer model. The results showed that paeonol
(150 mg/kg and 300 mg/kg) effectively reduced the weight of EMT6 breast tumor. Compared with the control
group, paeonol significantly increased the number of tumor cells in G0/G1 phase, increased the number
of cells in apoptosis and decreased the number of cells in S phase and G2/M, inhibited the expression
of mutant p53, Bcl-2 and C-erbB-2 protein. The mechanisms of paeonol of antitumor effects might be associated
with inhibition of tumor cells in G0/G1 phase, inducing cell apoptosis and inhibiting the expression
of mutant p53, Bcl-2 and C-erbB-2 protein. |
| format |
Articulo Articulo |
| author |
Tian, Yongzhi Wang, Jianjie Li, Qingwang Ou, Yetao Li, Chunjiang Sun, Xiaoxin |
| author_facet |
Tian, Yongzhi Wang, Jianjie Li, Qingwang Ou, Yetao Li, Chunjiang Sun, Xiaoxin |
| author_sort |
Tian, Yongzhi |
| title |
Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| title_short |
Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| title_full |
Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| title_fullStr |
Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| title_full_unstemmed |
Antitumor effects of paeonol on mice bearing EMT6 breast Infiltrating ductal carcinoma |
| title_sort |
antitumor effects of paeonol on mice bearing emt6 breast infiltrating ductal carcinoma |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7920 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_7.pdf |
| work_keys_str_mv |
AT tianyongzhi antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma AT wangjianjie antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma AT liqingwang antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma AT ouyetao antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma AT lichunjiang antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma AT sunxiaoxin antitumoreffectsofpaeonolonmicebearingemt6breastinfiltratingductalcarcinoma |
| bdutipo_str |
Repositorios |
| _version_ |
1764820486364069888 |