New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups
New rapid first-derivative spectrophotometric (UVDS) and a stability-indicating high performance liquid chromatographic (HPLC) methods were developed, validated and successfully applied in the analysis of loratadine (LT) in tablets and syrups. In the UVDS method, 0.1 M HCl was used as solvent. The m...
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7914 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_1.pdf |
| Aporte de: |
| id |
I19-R120-10915-7914 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología assay methods; first-derivative spectrophotometry; liquid chromatography; loratadine Cromatografía |
| spellingShingle |
Farmacia Farmacología assay methods; first-derivative spectrophotometry; liquid chromatography; loratadine Cromatografía Nogueira, Nayane M. Alves, João M. P. Santoro, Maria Ines Rocha Miritello Singh, Anil K. New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| topic_facet |
Farmacia Farmacología assay methods; first-derivative spectrophotometry; liquid chromatography; loratadine Cromatografía |
| description |
New rapid first-derivative spectrophotometric (UVDS) and a stability-indicating high performance liquid chromatographic (HPLC) methods were developed, validated and successfully applied in the analysis of loratadine (LT) in tablets and syrups. In the UVDS method, 0.1 M HCl was used as solvent. The measurements were made at 312.4 nm in the first order derivative spectra. The HPLC method was carried out on a RP-18 column with a mobile phase composed of methanol-water-tetrahydrofuran (50:30:20, v/v/v). UV detection was made at 247 nm. For HPLC methods the total analysis time was <3min, adequate for routine quality control of tablets and syrups containing loratadine. |
| format |
Articulo Articulo |
| author |
Nogueira, Nayane M. Alves, João M. P. Santoro, Maria Ines Rocha Miritello Singh, Anil K. |
| author_facet |
Nogueira, Nayane M. Alves, João M. P. Santoro, Maria Ines Rocha Miritello Singh, Anil K. |
| author_sort |
Nogueira, Nayane M. |
| title |
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| title_short |
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| title_full |
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| title_fullStr |
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| title_full_unstemmed |
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| title_sort |
new rapid derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7914 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_1.pdf |
| work_keys_str_mv |
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Repositorios |
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