Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects
Increased oxidative stress is implicated in several diseases. D-002, a mixture of six higher aliphatic alcohols purified from beeswax, and grape seed extract (GSE) (rich in flavonoids), have been shown antioxidant effects. This randomised, double-blinded study compared the effects of both substanc...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7902 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_14.pdf |
| Aporte de: |
| id |
I19-R120-10915-7902 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología antioxidant; beeswax alcohols; D-002; grape seed fruit extract; oxidative variables Estrés oxidativo Tratamiento médico |
| spellingShingle |
Farmacia Farmacología antioxidant; beeswax alcohols; D-002; grape seed fruit extract; oxidative variables Estrés oxidativo Tratamiento médico Rodriguez, Iván Illnait, José Molina, Vivian Oyarzábal, Ambar Fernández, Lilia Mesa, Meylis Más, Rosa Mendoza, Sarahí Gámez, Rafael Jiménez, Sonia Ruiz, Dalmer Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| topic_facet |
Farmacia Farmacología antioxidant; beeswax alcohols; D-002; grape seed fruit extract; oxidative variables Estrés oxidativo Tratamiento médico |
| description |
Increased oxidative stress is implicated in several diseases. D-002, a mixture of six higher
aliphatic alcohols purified from beeswax, and grape seed extract (GSE) (rich in flavonoids), have been
shown antioxidant effects. This randomised, double-blinded study compared the effects of both substances
on plasma malondialdehyde (MDA), total hydroxyperoxides (TOH), carbonyl groups (CG) and blood superoxide
dismutase (SOD) in healthy volunteers. Fifty eligible subjects were randomized to D-002 (50
mg/day) or GSE (85 mg proanthocianydine/day) for 8 weeks. Both D-002 and GSE reduced significantly
plasma MDA (30.0% and 34.0%, respectively), TOH (31.6% and 34.0%, respectively) and CG (21.4% and
14.3 %, respectively), but unchanged SOD. No significant differences between groups were found. Both
treatments were well tolerated. No subject dropped out because of adverse experiences (AE). Then, D-002
and GSE administered for 8 weeks were similarly effective for lowering plasma markers of lipid and protein
oxidation, and similarly safe. |
| format |
Articulo Articulo |
| author |
Rodriguez, Iván Illnait, José Molina, Vivian Oyarzábal, Ambar Fernández, Lilia Mesa, Meylis Más, Rosa Mendoza, Sarahí Gámez, Rafael Jiménez, Sonia Ruiz, Dalmer |
| author_facet |
Rodriguez, Iván Illnait, José Molina, Vivian Oyarzábal, Ambar Fernández, Lilia Mesa, Meylis Más, Rosa Mendoza, Sarahí Gámez, Rafael Jiménez, Sonia Ruiz, Dalmer |
| author_sort |
Rodriguez, Iván |
| title |
Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| title_short |
Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| title_full |
Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| title_fullStr |
Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| title_full_unstemmed |
Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects |
| title_sort |
comparison of the antioxidant effects of d-002 (beeswax alcohols) and grape seed extract (gse) on plasma oxidative variables in healthy subjects |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7902 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_14.pdf |
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Repositorios |
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