Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat
The present study was designed to investigate the antiulcer activity of ethyl acetate extract of Citrus decumana (grapefruit) peels. The antiulcerogenic activity was evaluated in water immersion and hypothermic restraint stress models at different doses (150, 250 and 350 mg/kg). The antiulcer potent...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7870 http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-7870 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia antiulcer activity; citrus decumana peels; oxidative stress markers Farmacología Plantas medicinales |
| spellingShingle |
Farmacia antiulcer activity; citrus decumana peels; oxidative stress markers Farmacología Plantas medicinales Sood, Shailja Muthuraman, Arunachalam Arora, Bhawna Bansal, Stuti Bali, Manoj Sharma, Pritam D. Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| topic_facet |
Farmacia antiulcer activity; citrus decumana peels; oxidative stress markers Farmacología Plantas medicinales |
| description |
The present study was designed to investigate the antiulcer activity of ethyl acetate extract of Citrus decumana (grapefruit) peels. The antiulcerogenic activity was evaluated in water immersion and hypothermic restraint stress models at different doses (150, 250 and 350 mg/kg). The antiulcer potential of the extract was assessed by determining and comparing the ulcerative index and biochemical estimation was carried out using various oxidative stress markers i.e., TBARS, GSH, SOD and CAT in the blood and tissue samples. The highest dose (350 mg/kg) of the extract showed significant decrease in the ulcerative index and TBARS level, whereas there was increase in the GSH, SOD and CAT levels. Whereas the lowest and medium dose (150 mg/kg and 250mg/kg) did not produce any significant results. Therefore, our study indicate that the Citrus decumana peel extract may be used as a natural therapeutic agent in the treatment of peptic ulcers. |
| format |
Articulo Articulo |
| author |
Sood, Shailja Muthuraman, Arunachalam Arora, Bhawna Bansal, Stuti Bali, Manoj Sharma, Pritam D. |
| author_facet |
Sood, Shailja Muthuraman, Arunachalam Arora, Bhawna Bansal, Stuti Bali, Manoj Sharma, Pritam D. |
| author_sort |
Sood, Shailja |
| title |
Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| title_short |
Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| title_full |
Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| title_fullStr |
Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| title_full_unstemmed |
Potential effect of Citrus decumana extract on stress induced peptic ulcer in rat |
| title_sort |
potential effect of citrus decumana extract on stress induced peptic ulcer in rat |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7870 http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_7.pdf |
| work_keys_str_mv |
AT soodshailja potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat AT muthuramanarunachalam potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat AT arorabhawna potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat AT bansalstuti potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat AT balimanoj potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat AT sharmapritamd potentialeffectofcitrusdecumanaextractonstressinducedpepticulcerinrat |
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Repositorios |
| _version_ |
1764820486485704704 |