Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
The aim of this study was to determine the prognostic value of expression of Excision Repair Cross-complementation Group 1 (ERCC1), B cell lymphoma/lewkmia-2 (Bcl-2) and metallothionein (MT) by immunohistochemically staining tumor specimens from 78 patients with advanced non-small-cell lung cance...
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Autores principales: | , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2009
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7842 http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_4_1ER34O4VWY.pdf |
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id |
I19-R120-10915-7842 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance Quimioterapia Farmacología |
spellingShingle |
Farmacia Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance Quimioterapia Farmacología Ma, Haiqing Sun, Huanhuan Huang, Fuxi Li, Jing Cao, Xiaolong Jiang, Wenqi Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
topic_facet |
Farmacia Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance Quimioterapia Farmacología |
description |
The aim of this study was to determine the prognostic value of expression of Excision Repair
Cross-complementation Group 1 (ERCC1), B cell lymphoma/lewkmia-2 (Bcl-2) and metallothionein (MT)
by immunohistochemically staining tumor specimens from 78 patients with advanced non-small-cell lung
cancer (NSCLC) treated with cisplatin-based chemotherapy. The result showed that positive expression of
ERCC1 was associated both with short survival (10.45 months vs. 14.38 months, log-rank p = 0.003) and
poor response to cisplatin-based chemotherapy (p = 0.003) when compared with negative group. But expression
of Bcl-2 and MT was not associated with response to chemotherapy and survival. Multivariate
analysis confirmed that expression of ERCC1 was an independent variable related to overall survival (p =
0.013). These data support the role of RECC1 expression as a candidate predictor for the survival of patients
with advanced NSCLC treated with cisplatin-based chemotherapy. |
format |
Articulo Articulo |
author |
Ma, Haiqing Sun, Huanhuan Huang, Fuxi Li, Jing Cao, Xiaolong Jiang, Wenqi |
author_facet |
Ma, Haiqing Sun, Huanhuan Huang, Fuxi Li, Jing Cao, Xiaolong Jiang, Wenqi |
author_sort |
Ma, Haiqing |
title |
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
title_short |
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
title_full |
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
title_fullStr |
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
title_full_unstemmed |
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
title_sort |
expression of ercc1, bcl-2, mt and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy |
publishDate |
2009 |
url |
http://sedici.unlp.edu.ar/handle/10915/7842 http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_4_1ER34O4VWY.pdf |
work_keys_str_mv |
AT mahaiqing expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy AT sunhuanhuan expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy AT huangfuxi expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy AT lijing expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy AT caoxiaolong expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy AT jiangwenqi expressionofercc1bcl2mtandtheirclinicalsignificanceinadvancednonsmallcelllungcancertreatedwithcisplatinbasedchemotherapy |
bdutipo_str |
Repositorios |
_version_ |
1764820485942542336 |