Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn

The present study was designed to investigate antioxidant, antidiarrhoeal and cytotoxic potential of hydromethanolic extract of the fruit rind of Punica granatum Linn. A dose dependent scavenging of DPPH radical and NO was observed with significant total antioxidant capacity with the plant extract i...

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Detalles Bibliográficos
Autores principales: Hasan, Raquibul, Hossain, Mokarram, Akter, Raushanara, Jamila, Mariam, Mazumder, Mohammed Ehsanul H., Islam, Imamul, Faruque, Abdullah, Ghani, Abdul, Rahman, Shafiqur
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Farmacología
antioxidante; antidiarreico; citotoxicidad; DPPH; Punica granatum
Extractos de plantas
antioxidant; antidiarrhoeal; cytotoxicity; DPPH; Punica granatum
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7836
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_21_432V85WS6A.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7836
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
antioxidante; antidiarreico; citotoxicidad; DPPH; Punica granatum
Extractos de plantas
antioxidant; antidiarrhoeal; cytotoxicity; DPPH; Punica granatum
spellingShingle Farmacia
Farmacología
antioxidante; antidiarreico; citotoxicidad; DPPH; Punica granatum
Extractos de plantas
antioxidant; antidiarrhoeal; cytotoxicity; DPPH; Punica granatum
Hasan, Raquibul
Hossain, Mokarram
Akter, Raushanara
Jamila, Mariam
Mazumder, Mohammed Ehsanul H.
Islam, Imamul
Faruque, Abdullah
Ghani, Abdul
Rahman, Shafiqur
Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
topic_facet Farmacia
Farmacología
antioxidante; antidiarreico; citotoxicidad; DPPH; Punica granatum
Extractos de plantas
antioxidant; antidiarrhoeal; cytotoxicity; DPPH; Punica granatum
description The present study was designed to investigate antioxidant, antidiarrhoeal and cytotoxic potential of hydromethanolic extract of the fruit rind of Punica granatum Linn. A dose dependent scavenging of DPPH radical and NO was observed with significant total antioxidant capacity with the plant extract in 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, total antioxidant capacity and nitric oxide (NO) scavenging assays. The extract was also studied for antidiarrhoeal property using castor oil and MgSO<sub>4</sub> -induced diarrhoeal model, and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts significantly (p < 0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. The extract also displayed strong cytotoxic potential with LC<sub>50</sub> value of 10 μg/ml in brine shrimp lethality bioassay.
format Articulo
Articulo
author Hasan, Raquibul
Hossain, Mokarram
Akter, Raushanara
Jamila, Mariam
Mazumder, Mohammed Ehsanul H.
Islam, Imamul
Faruque, Abdullah
Ghani, Abdul
Rahman, Shafiqur
author_facet Hasan, Raquibul
Hossain, Mokarram
Akter, Raushanara
Jamila, Mariam
Mazumder, Mohammed Ehsanul H.
Islam, Imamul
Faruque, Abdullah
Ghani, Abdul
Rahman, Shafiqur
author_sort Hasan, Raquibul
title Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
title_short Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
title_full Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
title_fullStr Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
title_full_unstemmed Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn
title_sort antioxidant, antidiarrhoeal and cytotoxic properties of punica granatum linn
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7836
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_21_432V85WS6A.pdf
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