Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina

The chloroform extract of Cladonia substellata Vainio was assayed against larvae of Aedes aegypti, the mosquito vector of Dengue fever and Artemia salina. The extract was tested at concentrations ranging from 1 to 15 ppm in an aqueous medium for 24 h. LC<sub>50</sub> and LC<sub>90&...

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Autores principales:	Bomfim, Rangel R., Araújo, Adriano A. S., Cuadros-Orellana, Sara, Melo, Marcélia G.D., Quintans Júnior, Lucindo José, Cavalcanti, Sócrates C.H.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia Aedes aegypti; Artemia salina; Cladonia substellata; larvicidal activity; usnic acid Plantas medicinales Extractos de plantas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7804 http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_1_OAQ22XY027.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7804
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Aedes aegypti; Artemia salina; Cladonia substellata; larvicidal activity; usnic acid Plantas medicinales Extractos de plantas
spellingShingle	Farmacia Aedes aegypti; Artemia salina; Cladonia substellata; larvicidal activity; usnic acid Plantas medicinales Extractos de plantas Bomfim, Rangel R. Araújo, Adriano A. S. Cuadros-Orellana, Sara Melo, Marcélia G.D. Quintans Júnior, Lucindo José Cavalcanti, Sócrates C.H. Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
topic_facet	Farmacia Aedes aegypti; Artemia salina; Cladonia substellata; larvicidal activity; usnic acid Plantas medicinales Extractos de plantas
description	The chloroform extract of Cladonia substellata Vainio was assayed against larvae of Aedes aegypti, the mosquito vector of Dengue fever and Artemia salina. The extract was tested at concentrations ranging from 1 to 15 ppm in an aqueous medium for 24 h. LC<sub>50</sub> and LC<sub>90</sub> were evaluated. Since the chloroform extract proved to be lethal for third to fourth instar larvae, downstream processing was undertaken to purify the active agents in the extract. The major compound in the chloroform extract was purified by crystallization followed by column chromatography to yield yellow crystals. Furthermore, usnic acid (UA) was evaluated for its larvicidal potential. The major compound in the chloroform extract, UA, exhibited LC<sub>50</sub> of 6.6 ppm (6.1 to 7.0 ppm). Therefore, UA is most likely the active principle in C. substellata. UA showed to be toxic to A. salina, a reference organism in assays to evaluate the potential toxicity hazard to invertebrates in ecosystems.
format	Articulo Comunicacion
author	Bomfim, Rangel R. Araújo, Adriano A. S. Cuadros-Orellana, Sara Melo, Marcélia G.D. Quintans Júnior, Lucindo José Cavalcanti, Sócrates C.H.
author_facet	Bomfim, Rangel R. Araújo, Adriano A. S. Cuadros-Orellana, Sara Melo, Marcélia G.D. Quintans Júnior, Lucindo José Cavalcanti, Sócrates C.H.
author_sort	Bomfim, Rangel R.
title	Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
title_short	Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
title_full	Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
title_fullStr	Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
title_full_unstemmed	Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina
title_sort	larvicidal activity of cladonia substellata extract and usnic acid against aedes aegypti and artemia salina
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7804 http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_1_OAQ22XY027.pdf
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Larvicidal activity of Cladonia substellata extract and usnic acid against Aedes aegypti and Artemia salina

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