Antiviral activity of carrageenans from marine red algae
Three carrageenan representatives of each structural type: λ- and ι –family (Gigartina acicularis), ι-family (Euchema denticulatum) and κ –family (Kappaphycus cottonii) have been tested for their in vitro antiviral activity. The carrageenans proved to be potent inhibitors of herpes human virus type...
Guardado en:
Autores principales: | , , , |
---|---|
Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2009
|
Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7781 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_18_Q6BLEVWVR0.pdf |
Aporte de: |
id |
I19-R120-10915-7781 |
---|---|
record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae |
spellingShingle |
Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne Antiviral activity of carrageenans from marine red algae |
topic_facet |
Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae |
description |
Three carrageenan representatives of each structural type: λ- and ι –family (Gigartina acicularis), ι-family (Euchema denticulatum) and κ –family (Kappaphycus cottonii) have been tested for their in vitro antiviral activity. The carrageenans proved to be potent inhibitors of herpes human virus type 1 (HHV-1) and Poliovirus. The best results were obtained with carrageenans from Gigartina acicularis and Euchema denticulatum, which are more sulfated than those from Kappaphycus cottonii. The selective index values (CC50 /ID50 ) ranged from more than 22 to more than 545 for HHV-1 and more than 6.6 to more than 32 for Poliovirus. No citotoxic effects were observed. At 0.75 mg/ml, none of the carrageenans tested showed a virucidal activity against HHV-1 or Poliovirus. Carrageenans from Euchema denticulatum (ι- family) and Gigartina acicularis (λ- and ι –family) exerted their antiviral effect via, in part, by a lower inhibition of the virus attachment and by the interference in a subsequent stage of the virus replicative cycle. The κ-carrageenan from Kappaphycus cottonii exerted its antiviral effect mainly by a lower inhibition of the virus attachment. In cultures treated with carrageenans from Euchema denticulatum (ι-family) and Gigartina acicularis (λ- and ι –family), the HHV-1 viral DNA synthesis had a reduction of threefold and twofold with 0.75 mg/ml, respectively. |
format |
Articulo Articulo |
author |
Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne |
author_facet |
Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne |
author_sort |
Montanha, Jarbas |
title |
Antiviral activity of carrageenans from marine red algae |
title_short |
Antiviral activity of carrageenans from marine red algae |
title_full |
Antiviral activity of carrageenans from marine red algae |
title_fullStr |
Antiviral activity of carrageenans from marine red algae |
title_full_unstemmed |
Antiviral activity of carrageenans from marine red algae |
title_sort |
antiviral activity of carrageenans from marine red algae |
publishDate |
2009 |
url |
http://sedici.unlp.edu.ar/handle/10915/7781 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_18_Q6BLEVWVR0.pdf |
work_keys_str_mv |
AT montanhajarbas antiviralactivityofcarrageenansfrommarineredalgae AT bourgougnonnathalie antiviralactivityofcarrageenansfrommarineredalgae AT boustiejoel antiviralactivityofcarrageenansfrommarineredalgae AT amorosmaryvonne antiviralactivityofcarrageenansfrommarineredalgae |
bdutipo_str |
Repositorios |
_version_ |
1764820485105778689 |