Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films
In the present study, the influence of polymeric concentration, its blend and drug loading dose on the in vitro drug release pattern of alfuzosin hydrochloride from its transdermal patches has been investigated. Ratio of EC and PVP and drug loading dose were selected as independent variables and t...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7726 http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_9_2875GL94O9.pdf |
| Aporte de: |
| id |
I19-R120-10915-7726 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia alfuzosin hydrochloride; drug release; FT IR; polymeric system; SEM; Transdermal delivery Medicamento Evaluación de drogas |
| spellingShingle |
Farmacia alfuzosin hydrochloride; drug release; FT IR; polymeric system; SEM; Transdermal delivery Medicamento Evaluación de drogas Pattnaik, Satyanarayan Swain, Kalpana Mallick, Subrata Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| topic_facet |
Farmacia alfuzosin hydrochloride; drug release; FT IR; polymeric system; SEM; Transdermal delivery Medicamento Evaluación de drogas |
| description |
In the present study, the influence of polymeric concentration, its blend and drug loading
dose on the in vitro drug release pattern of alfuzosin hydrochloride from its transdermal patches has been
investigated. Ratio of EC and PVP and drug loading dose were selected as independent variables and their
influence on the percentage drug released at 24 h (Q24), drug release rate (KH) and time taken for 50%
drug release (t50%) were studied using statistical experimental designing. Ratio of EC and PVP was found
to be the main influential factor for all the dependent variables studied. Drug loading dose was also found
to influence the dependent variables but to a lesser extent. Physicochemical parameters of the prepared
patches were also evaluated. This study could be used as a screening method for further development of
transdermal delivery of alfuzosin hydrochloride and skin permeation studies. |
| format |
Articulo Articulo |
| author |
Pattnaik, Satyanarayan Swain, Kalpana Mallick, Subrata |
| author_facet |
Pattnaik, Satyanarayan Swain, Kalpana Mallick, Subrata |
| author_sort |
Pattnaik, Satyanarayan |
| title |
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| title_short |
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| title_full |
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| title_fullStr |
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| title_full_unstemmed |
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films |
| title_sort |
influence of polymeric system and loading dose on drug release from alfuzosin hydrochloride transdermal films |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7726 http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_9_2875GL94O9.pdf |
| work_keys_str_mv |
AT pattnaiksatyanarayan influenceofpolymericsystemandloadingdoseondrugreleasefromalfuzosinhydrochloridetransdermalfilms AT swainkalpana influenceofpolymericsystemandloadingdoseondrugreleasefromalfuzosinhydrochloridetransdermalfilms AT mallicksubrata influenceofpolymericsystemandloadingdoseondrugreleasefromalfuzosinhydrochloridetransdermalfilms |
| bdutipo_str |
Repositorios |
| _version_ |
1764820486437470211 |