Protective effect of D-003 on renal ischemia-reperfusion in rats
The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage, were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham oper...
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Autores principales: | , , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2009
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Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7718 http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_1_9BG1IL2E80.pdf |
Aporte de: |
id |
I19-R120-10915-7718 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Medicamento creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax Farmacología |
spellingShingle |
Farmacia Medicamento creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax Farmacología Carbajal, Daisy Noa, Miriam Ravelo, Yazmin Arruzazabala, María de Lourdes Más, Rosa Valle, Maikel Mendoza, Nilda Protective effect of D-003 on renal ischemia-reperfusion in rats |
topic_facet |
Farmacia Medicamento creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax Farmacología |
description |
The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with
antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage,
were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham operation
or renal I/R. One group was treated orally with the vehicle, two were treated with D-003 (250 and 500
mg/kg) and other with GSE (200 mg/kg). Renal morphological alterations were assessed by histopathological
examination of haematoxylin-eosin stained. After 24 h of post-ischemic acute renal failure, serum creatinine
levels was increased, effect that was significantly decreased by about 30 % and 60 % with D-003
and with GSE, respectively. Compared with sham rats, ischemic controls demonstrated severe damage of
renal function and morphology, while both D-003 and GSE treatments protected against these I/R-induced
histological abnormalities too. D-003 protected moderately against the increase of serum creatinine and
histological findings of I/R-induced renal injury in rats. |
format |
Articulo Articulo |
author |
Carbajal, Daisy Noa, Miriam Ravelo, Yazmin Arruzazabala, María de Lourdes Más, Rosa Valle, Maikel Mendoza, Nilda |
author_facet |
Carbajal, Daisy Noa, Miriam Ravelo, Yazmin Arruzazabala, María de Lourdes Más, Rosa Valle, Maikel Mendoza, Nilda |
author_sort |
Carbajal, Daisy |
title |
Protective effect of D-003 on renal ischemia-reperfusion in rats |
title_short |
Protective effect of D-003 on renal ischemia-reperfusion in rats |
title_full |
Protective effect of D-003 on renal ischemia-reperfusion in rats |
title_fullStr |
Protective effect of D-003 on renal ischemia-reperfusion in rats |
title_full_unstemmed |
Protective effect of D-003 on renal ischemia-reperfusion in rats |
title_sort |
protective effect of d-003 on renal ischemia-reperfusion in rats |
publishDate |
2009 |
url |
http://sedici.unlp.edu.ar/handle/10915/7718 http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_1_9BG1IL2E80.pdf |
work_keys_str_mv |
AT carbajaldaisy protectiveeffectofd003onrenalischemiareperfusioninrats AT noamiriam protectiveeffectofd003onrenalischemiareperfusioninrats AT raveloyazmin protectiveeffectofd003onrenalischemiareperfusioninrats AT arruzazabalamariadelourdes protectiveeffectofd003onrenalischemiareperfusioninrats AT masrosa protectiveeffectofd003onrenalischemiareperfusioninrats AT vallemaikel protectiveeffectofd003onrenalischemiareperfusioninrats AT mendozanilda protectiveeffectofd003onrenalischemiareperfusioninrats |
bdutipo_str |
Repositorios |
_version_ |
1764820485188616193 |