Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)

Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open f...

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Autores principales: Provensi, Gustavo, Nöel, François, Lopes, Daniela V.S., Fenner, Raquel, Betti, Andresa H., Costa, Fernanda de, Morais, Everton C., Grosmann, Grace, Rates, Stela M.K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Farmacia
Extractos de plantas
anxiolytic; Passiflora alata; sedative
Farmacología
Efectos fisiológicos de las drogas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7700
http://www.latamjpharm.org/trabajos/27/6/LAJOP_27_6_1_7_84873RKMDB.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7700
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Extractos de plantas
anxiolytic; Passiflora alata; sedative
Farmacología
Efectos fisiológicos de las drogas
spellingShingle Farmacia
Extractos de plantas
anxiolytic; Passiflora alata; sedative
Farmacología
Efectos fisiológicos de las drogas
Provensi, Gustavo
Nöel, François
Lopes, Daniela V.S.
Fenner, Raquel
Betti, Andresa H.
Costa, Fernanda de
Morais, Everton C.
Grosmann, Grace
Rates, Stela M.K.
Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
topic_facet Farmacia
Extractos de plantas
anxiolytic; Passiflora alata; sedative
Farmacología
Efectos fisiológicos de las drogas
description Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open field and [3H]flunitrazepam binding assays. The only effect presented by AQ (300 mg/kg, p.o.) was on the barbiturate sleeping time, indicating a hypnotic effect. The HE extract (300 and 600 mg/kg, p.o.) also increased the barbiturate sleeping time and reduced the locomotor activity (at 600 mg/kg, p.o.), pointing to a sedative effect. In addition HE showed an anxiolytic-like effect (300 mg/kg, p.o.) in the elevated plus maze test which was blocked by flumazenil (6 mg/kg, i.p.). Nevertheless HE did not displace [3H]flunitrazepam binding to rat brain synaptosomes in concentrations up to 1000 μg/mL. As a conclusion, we showed that the anxiolytic effect of P. alata in mice depends on the dose and solvent used for the extract preparation, and this effect cannot be attributed to the direct activation of the central benzodiazepine site by the chemical constituents of the extract. It is possible that their metabolites or an indirect effect on benzodiazepine- GABAA receptor complex mediate the observed anxiolytic effect.
format Articulo
Articulo
author Provensi, Gustavo
Nöel, François
Lopes, Daniela V.S.
Fenner, Raquel
Betti, Andresa H.
Costa, Fernanda de
Morais, Everton C.
Grosmann, Grace
Rates, Stela M.K.
author_facet Provensi, Gustavo
Nöel, François
Lopes, Daniela V.S.
Fenner, Raquel
Betti, Andresa H.
Costa, Fernanda de
Morais, Everton C.
Grosmann, Grace
Rates, Stela M.K.
author_sort Provensi, Gustavo
title Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
title_short Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
title_full Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
title_fullStr Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
title_full_unstemmed Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)
title_sort participation of gaba-benzodiazepine receptor complex in the anxiolytic effect of passiflora alata curtis (passifloraceae)
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/7700
http://www.latamjpharm.org/trabajos/27/6/LAJOP_27_6_1_7_84873RKMDB.pdf
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