Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture

The synthesis and spectral and magnetic characterization of VO(2+) complexes with Ibuprofen (2-(4-isobutylphenyl)propionic acid), Naproxen (6-methoxy-alpha-methyl-2-naphthalene acetic acid) and Tolmetin (1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid) were studied. The complexes [VO(Ibu)(2)]...

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Detalles Bibliográficos
Autores principales: Etcheverry, Susana B., Barrio, Daniel Alejandro, Cortizo, Ana María, Williams, Patricia Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2002
Materias:
Ciencias Exactas
Anti-inflammatory drugs; Vanadyl complexes; Spectroscopy; Osteoblast proliferation
Química
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/76583
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-76583
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Anti-inflammatory drugs; Vanadyl complexes; Spectroscopy; Osteoblast proliferation
Química
spellingShingle Ciencias Exactas
Anti-inflammatory drugs; Vanadyl complexes; Spectroscopy; Osteoblast proliferation
Química
Etcheverry, Susana B.
Barrio, Daniel Alejandro
Cortizo, Ana María
Williams, Patricia Ana María
Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
topic_facet Ciencias Exactas
Anti-inflammatory drugs; Vanadyl complexes; Spectroscopy; Osteoblast proliferation
Química
description The synthesis and spectral and magnetic characterization of VO(2+) complexes with Ibuprofen (2-(4-isobutylphenyl)propionic acid), Naproxen (6-methoxy-alpha-methyl-2-naphthalene acetic acid) and Tolmetin (1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid) were studied. The complexes [VO(Ibu)(2)] x 5CH(3)OH, [VO(Nap)(2)] x 5CH(3)OH and [VO(Tol)(2)] were obtained from methanolic solutions under nitrogen atmosphere. The biological activities of these complexes on the proliferation of two osteoblast-like cells in culture (MC3T3E1 and UMR106) were compared with that of the vanadyl(IV) cation. The complexes exhibited different effects depending on the concentration and the cellular type, while no effect was observed for their parent drugs.
format Articulo
Articulo
author Etcheverry, Susana B.
Barrio, Daniel Alejandro
Cortizo, Ana María
Williams, Patricia Ana María
author_facet Etcheverry, Susana B.
Barrio, Daniel Alejandro
Cortizo, Ana María
Williams, Patricia Ana María
author_sort Etcheverry, Susana B.
title Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
title_short Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
title_full Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
title_fullStr Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
title_full_unstemmed Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) : Bioactivity on osteoblast-like cells in culture
title_sort three new vanadyl(iv) complexes with non-steroidal anti-inflammatory drugs (ibuprofen, naproxen and tolmetin) : bioactivity on osteoblast-like cells in culture
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/76583
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